Serotonin as a regulator of hypothalamic-pituitary-interrenal activity in teleost fish

被引：187

作者：

Winberg, S ^{[1
]}

Nilsson, A ^{[1
]}

Hylland, P ^{[1
]}

Soderstom, V ^{[1
]}

Nilsson, GE ^{[1
]}

机构：

[1] UNIV OSLO,DEPT BIOL,N-0316 OSLO,NORWAY

来源：

NEUROSCIENCE LETTERS | 1997年 / 230卷 / 02期

关键词：

serotonin; cortisol; serotonin(1A) receptors; Rainbow trout; stress; 8-hydroxy-2-(di-n-propylamino)-tetralin;

D O I：

10.1016/S0304-3940(97)00488-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Evidence for the presence of a serotonin(1A), (5-HT1A) receptor subtype in the salmonid fish brain has recently been presented. In the present study the potent 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) was tested for its effect on plasma cortisol concentrations in rainbow trout (Oncorhynchus mykiss). Blood was sampled and 8-OH-DPAT administered through a catheter in the dorsal aorta. Thirty minutes after the injection of 40 mu g of 8-OH DPAT/kg, plasma cortisol levels had increased from 12 to 149 ng/ml, whereupon they fell, reaching baseline levels after 4 h. The effect of 1-40 mu g 8-OH-DPAT/kg on plasma cortisol concentrations was dose-dependent. The results lends further support to the hypothesis that the brain serotonergic system plays a key role in integrating autonomic, behavioral and neuroendocrine stress-responses in fish as well as mammals, suggesting that not only the structural and biochemical organization, but also the function of the serotonergic system has been conserved during vertebrate evolution. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：113 / 116

页数：4

共 38 条

[1] SEROTONIN, BUT NOT DOPAMINE, METABOLITES ARE INCREASED IN SELECTED BRAIN-REGIONS OF SUBORDINATE MALE-RATS IN A COLONY ENVIRONMENT [J].