The many HATs of transcription coactivators

被引：289

作者：

Brown, CE ^{[1
]}

Lechner, T ^{[1
]}

Howe, L ^{[1
]}

Workman, JL ^{[1
]}

机构：

[1] Penn State Univ, Dept Biochem & Mol Biol, Howard Hughes Med Inst, University Pk, PA 16802 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2000年 / 25卷 / 01期

关键词：

D O I：

10.1016/S0968-0004(99)01516-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Histone acetylation is closely linked to gene transcription. The identification of histone acetyltransferases (HATs) and the large multiprotein complexes in which they reside has yielded important insights into how these enzymes regulate transcription. The demonstration that HAT complexes interact with sequence-specific activator proteins illustrates how these complexes target specific genes. In addition to histones, some HATs can acetylate nonhistone proteins suggesting multiple roles for these enzymes.

引用

页码：15 / 19

页数：5

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