Amplified microgravimetric gene sensor using Au nanoparticle modified oligonucleotides

被引：101

作者：

Zhou, XC ^{[1
]}

O'Shea, SJ

Li, SFY

机构：

[1] Natl Univ Singapore, Inst Mat Res & Engn, Singapore 119260, Singapore

[2] Natl Univ Singapore, Dept Chem, Singapore 119260, Singapore

[3] Inst Mat Res & Engn, Singapore 117602, Singapore

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 11期

关键词：

D O I：

10.1039/b001737j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel microgravimetric gene sensing system has been developed using an oligonucleotide anchored on the gold electrode of a quartz crystal microbalance and an Au nanoparticle modified oligonucleotide, both of which formed a sandwich-type ternary complex with the target DNA to give an amplified frequency response.

引用

页码：953 / 954

页数：2

共 11 条

[1] Amplified microgravimetric quartz crystal-microbalance analyses of oligonucleotide complexes: a route to a Tay-Sachs biosensor device [J].

Bardea, A ;

Dagan, A ;

Ben-Dov, I ;

Amit, B ;

Willner, I .

CHEMICAL COMMUNICATIONS, 1998, (07) :839-840

[2]

BIZET K, 1996, P 4 WORLD C BIOS BAN

[3] AMPLIFIED MASS IMMUNOSORBENT-ASSAY WITH A QUARTZ CRYSTAL MICROBALANCE [J].

EBERSOLE, RC ;

WARD, MD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (26) :8623-8628

[4] RECENT ADVANCES IN THE POLYMERASE CHAIN-REACTION [J].

ERLICH, HA ;

GELFAND, D ;

SNINSKY, JJ .

SCIENCE, 1991, 252 (5013) :1643-1651

[5] Direct monitoring of DNA polymerase reactions on a quartz-crystal microbalance [J].

Niikura, K ;

Matsuno, H ;

Okahata, Y .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (33) :8537-8538

[6] Kinetic measurements of DNA hybridisation an an oligonucleotide-immobilized 27-MHz quartz crystal microbalance [J].

Okahata, Y ;

Kawase, M ;

Niikura, K ;

Ohtake, F ;

Furusawa, H ;

Ebara, Y .

ANALYTICAL CHEMISTRY, 1998, 70 (07) :1288-1296

[7] One-pot colorimetric differentiation of polynucleotides with single base imperfections using gold nanoparticle probes [J].

Storhoff, JJ ;

Elghanian, R ;

Mucic, RC ;

Mirkin, CA ;

Letsinger, RL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (09) :1959-1964

[8] INTERFACIAL NUCLEIC-ACID HYBRIDIZATION STUDIED BY RANDOM PRIMER P-32 LABELING AND LIQUID-PHASE ACOUSTIC NETWORK ANALYSIS [J].

SU, HB ;

KALLURY, KMR ;

THOMPSON, M ;

ROACH, A .

ANALYTICAL CHEMISTRY, 1994, 66 (06) :769-777

[9] Dendritic nucleic acid probes for DNA biosensors [J].

Wang, J ;

Jiang, M ;

Nilsen, TW ;

Getts, RC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (32) :8281-8282

[10] Mismatch sensitive hybridization detection by peptide nucleic acids immobilized on a quartz crystal microbalance [J].

Wang, J ;

Nielsen, PE ;

Jiang, M ;

Cai, XH ;

Fernandes, JR ;

Grant, DH ;

Ozsoz, M ;

Beglieter, A ;

Mowat, M .

ANALYTICAL CHEMISTRY, 1997, 69 (24) :5200-5202

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