Chemoprevention of colorectal neoplasia: advances and controversies (the COX-2 story)

被引：6

作者：

Bresalier, Robert S. ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA

来源：

CURRENT OPINION IN GASTROENTEROLOGY | 2007年 / 23卷 / 01期

关键词：

chemoprevention; colorectal-cancer; cyclooxygenase; nonsteroidal anti-inflammatory drugs;

D O I：

10.1097/MOG.0b013e328011c482

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Purpose of review Colorectal cancer is prevalent, deadly and expensive to treat. Chemoprevention provides an opportunity to prevent colorectal cancer through prevention of precursor adenomas. Recent findings Three prospective randomized trials demonstrate significant reductions in new, sporadic adenoma formation in individuals taking COX-2 selective inhibitors compared to placebo, but with an associated increase in cardiovascular risk. Summary Chemoprevention of colorectal adenomas with COX-2 selective nonsteroidal anti-inflammatory drugs. is feasible, but these agents are unlikely to be used routinely for prevention of sporadic adenomas due to associated cardiovascular risk. Their use in other groups will depend on the answers to several questions regarding mechanisms of action and risk versus benefit.

引用

页码：44 / 47

页数：4

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