Anti-tumor effectiveness of electrochemotherapy with bleomycin is increased by TNF-alpha on SA-1 tumors in mice

被引：46

作者：

Sersa, G

Cemazar, M

Menart, V

GabercPorekar, V

Miklavcic, D

机构：

[1] LEK LJUBLJANA, R&D, LJUBLJANA 1526, SLOVENIA

[2] NATL INST CHEM, LJUBLJANA 1115, SLOVENIA

[3] UNIV LJUBLJANA, FAC ELECT ENGN, LJUBLJANA 1000, SLOVENIA

来源：

CANCER LETTERS | 1997年 / 116卷 / 01期

关键词：

electrochemotherapy; electroporation; bleomycin; tumor necrosis factor-alpha; sarcoma experimental;

D O I：

10.1016/S0304-3835(97)00170-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

With the aim to increase anti-tumor effectiveness of electrochemotherapy, adjuvant immunotherapy with tumor necrosis factor-alpha (TNF-alpha) was tested on tumors in mice. Increased anti-tumor effectiveness on SA-1 tumors was observed after combining TNF-alpha, injected either intratumorally or peritumorally, with electrochemotherapy using suboptimal dose of bleomycin (BLM). The increased anti-tumor effectiveness was neither the result of potentiated anti-tumor effectiveness of TNF-alpha due to exposure of tumors to electric pulses, nor due to interaction with BLM. Therefore, the effect of adjuvant TNF-alpha treatment might be immunomodulatory, augmenting the anti-tumor activity of electrochemotherapy, and possibly adding a systemic component to the localized electrochemotherapy treatment. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：85 / 92

页数：8

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