Poor Clinical Sensitivity of Rapid Antigen Test for Influenza A Pandemic (H1N1) 2009 Virus

被引：153

作者：

Drexler, Jan Felix ^{[1
]}

Helmer, Angelika ^{[1
]}

Kirberg, Heike ^{[1
]}

Reber, Ulrike ^{[1
]}

Panning, Marcus ^{[1
]}

Mueller, Marcel ^{[1
]}

Hoefling, Katja ^{[1
]}

Matz, Bertfried ^{[1
]}

Drosten, Christian ^{[1
]}

Eis-Huebinger, Anna Maria ^{[1
]}

机构：

[1] Univ Bonn, Med Ctr, Inst Virol, D-53127 Bonn, Germany

来源：

EMERGING INFECTIOUS DISEASES | 2009年 / 15卷 / 10期

关键词：

PCR; PERFORMANCE;

D O I：

10.3201/eid1510.091186

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Influenza A pandemic (H1N1) 2009 virus RNA was detected by reverse transcription-PCR in 144 clinical samples from Bonn, Germany. A common rapid antigen-based test detected the virus in only 11.1% of these samples. The paramount feature of rapid test-positive samples was high virus concentration. Antigen-based rapid tests appear unsuitable for virologic diagnostics in the current pandemic.

引用

页码：1662 / 1664

页数：3

共 15 条

[1] Comparison of two rapid influenza A/B test kits with reference methods showing high specificity and sensitivity for influenza A infection [J].

Booth, S ;

Baleriola, C ;

Rawlinson, WD .

JOURNAL OF MEDICAL VIROLOGY, 2006, 78 (05) :619-622

[2] Analytical sensitivity of rapid influenza antigen detection tests for swine-origin influenza virus (H1N1) [J].

Chan, K. H. ;

Lai, S. T. ;

Poon, L. L. M. ;

Guan, Y. ;

Yuen, K. Y. ;

Peiris, J. S. M. .

JOURNAL OF CLINICAL VIROLOGY, 2009, 45 (03) :205-207

[3] A Novel Diagnostic Target in the Hepatitis C Virus Genome [J].

Drexler, Jan Felix ;

Kupfer, Bernd ;

Petersen, Nadine ;

Tommasini Grotto, Rejane Maria ;

Corvino Rodrigues, Silvia Maria ;

Grywna, Klaus ;

Panning, Marcus ;

Annan, Augustina ;

Silva, Giovanni Faria ;

Douglas, Jill ;

Koay, Evelyn S. C. ;

Smuts, Heidi ;

Netto, Eduardo M. ;

Simmonds, Peter ;

de Moura Campos Pardini, Maria Ines ;

Roth, W. Kurt ;

Drosten, Christian .

PLOS MEDICINE, 2009, 6 (02) :210-220

[4]

FAIX DJ, 2009, N ENGL J MED 0629

[5] Comparison of the performance of the rapid antigen detection actim Influenza A&B test and RT-PCR in different respiratory specimens [J].

Ghebremedhin, B. ;

Engelmann, I. ;

Koenig, W. ;

Koenig, B. .

JOURNAL OF MEDICAL MICROBIOLOGY, 2009, 58 (03) :365-370

[6] Evaluation of multiple test methods for the detection of the novel 2009 influenza A (H1N1) during the New York City outbreak [J].

Ginocchio, Christine C. ;

Zhang, Frank ;

Manji, Ryhana ;

Arora, Suman ;

Bornfreund, Mark ;

Falk, Leon ;

Lotlikar, Madhavi ;

Kowerska, Margaret ;

Becker, George ;

Korologos, Diamanto ;

de Geronimo, Marcella ;

Crawford, James M. .

JOURNAL OF CLINICAL VIROLOGY, 2009, 45 (03) :191-195

[7] Performance of influenza rapid point-of-care tests in the detection of swine lineage A(H1N1) influenza viruses [J].

Hurt, Aeron C. ;

Baas, Chantal ;

Deng, Yi-Mo ;

Roberts, Sally ;

Kelso, Anne ;

Barr, Ian G. .

INFLUENZA AND OTHER RESPIRATORY VIRUSES, 2009, 3 (04) :171-176

[8] Real-time PCR compared to Binax NOW and cytospin-immunofluorescence for detection of influenza in hospitalized patients [J].

Landry, Marie L. ;

Cohen, Sandra ;

Ferguson, David .

JOURNAL OF CLINICAL VIROLOGY, 2008, 43 (02) :148-151

[9]

*R KOCH I, INFL A H1N1 SIT NEUE

[10]

*R KOCH I, SAIS AG INFL

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