A His-Pro-Aib peptide that exhibits an Asx-Pro-turn-like structure

被引：26

作者：

Blank, JT ^{[1
]}

Guerin, DJ ^{[1
]}

Miller, SJ ^{[1
]}

机构：

[1] Boston Coll, Dept Chem, Merkert Chem Ctr, Chestnut Hill, MA 02467 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 09期

关键词：

D O I：

10.1021/ol005700n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Small peptides 1 and 2, which differ only in that 1 possesses a BOC-Phe residue at the N-terminus, where 2 bears a BOC-(tau-benzyl)His, were found to exhibit very different structures. In both the solid state (X-ray) and in solution (NMR and in), peptide 1 exists as a beta-turn, whereas peptide 2 exists in a conformation that resembles the Asx-Pro motif.

引用

页码：1247 / 1249

页数：3

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