Synthesis of chroman analogues of lipoic acid and evaluation of their activity against reperfusion arrhythmias

被引：65

作者：

Koufaki, M

Detsi, A

Theodorou, E

Kiziridi, C

Calogeropoulou, T

Vassilopoulos, A

Kourounakis, AP

Rekka, E

Kourounakis, PN

Gaitanaki, C

Papazafiri, P

机构：

[1] Natl Hellen Res Fdn, Inst Organ & Pharmaceut Chem, Athens 11635, Greece

[2] Univ Athens, Sch Biol, Dept Anim & Human Physiol, Athens 15784, Greece

[3] Univ Athens, Sch Pharm, Dept Pharmaceut Chem, Athens 15771, Greece

[4] Aristotle Univ Thessaloniki, Sch Pharm, Dept Pharmaceut Chem, Thessaloniki 54006, Greece

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 18期

关键词：

chroman; lipoic acid; lipid peroxidation; reperfusion arrhythmias;

D O I：

10.1016/j.bmc.2004.07.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel hybrids of lipoic acid and trolox connected through triamine spacers as well as analogues in which the lipoic acid was attached at different positions of the chroman moiety of vitamin E through an amide bond, were synthesized and exhibited strong inhibition of the microsomal lipid peroxidation. Moreover, the new molecules, at 1 muM concentration, reduced reperfusion arrhythimas and MDA content on isolated rat heart preparations, with the 2- and 5-subtituted chromans possessing the better cardioprotective activity. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4835 / 4841

页数：7

共 19 条

[1] The pharmacology of the antioxidant lipoic acid [J].