An underlap field-effect transistor for electrical detection of influenza

被引：64

作者：

Lee, Kwang-Won ^{[1
]}

Choi, Sung-Jin ^{[1
]}

Ahn, Jae-Hyuk ^{[1
]}

Moon, Dong-Il ^{[1
]}

Park, Tae Jung ^{[2
,3
]}

Lee, Sang Yup ^{[2
,3
,4
,5
]}

Choi, Yang-Kyu ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Sch Elect Engn & Comp Sci, Div Elect Engn, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, BioProc Engn Res Ctr, Ctr Syst & Synthet Biotechnol, Taejon 305701, South Korea

[3] Korea Adv Inst Sci & Technol, Inst BioCentury, Taejon 305701, South Korea

[4] Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Dept Biol Sci, Taejon 305701, South Korea

[5] Korea Adv Inst Sci & Technol, Bioinformat Res Ctr, Taejon 305701, South Korea

来源：

APPLIED PHYSICS LETTERS | 2010年 / 96卷 / 03期

关键词：

biosensors; CMOS integrated circuits; field effect transistors; microorganisms; molecular biophysics; proteins; NANOWIRE NANOSENSORS;

D O I：

10.1063/1.3291617

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

An underlap channel-embedded field-effect transistor (FET) is proposed for label-free biomolecule detection. Specifically, silica binding protein fused with avian influenza (AI) surface antigen and avian influenza antibody (anti-AI) were designed as a receptor molecule and a target material, respectively. The drain current was significantly decreased after the binding of negatively charged anti-AI on the underlap channel. A set of control experiments supports that only the biomolecules on the underlap channel effectively modulate the drain current. With the merits of a simple fabrication process, complementary metal-oxide-semiconductor compatibility, and enhanced sensitivity, the underlap FET could be a promising candidate for a chip-based biosensor.

引用

页数：3

共 13 条

[1] Field-effect detection of chemical species with hybrid organic/inorganic transistors [J].