Modulating dendritic cells (DC) from immunogenic to tolerogenic responses: A novel mechanism of AZA/6-MP

被引：24

作者：

Aldinucci, Alessandra ^{[1
]}

Biagioli, Tiziana ^{[1
]}

Manuelli, Cinzia ^{[2
]}

Repice, Anna Maria ^{[1
]}

Massacesi, Luca ^{[1
]}

Ballerini, Clara ^{[1
]}

机构：

[1] Univ Florence, Dept Neurol Sci, I-50134 Florence, Italy

[2] Univ Florence, Dept Dermatol Sci, I-50134 Florence, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2010年 / 218卷 / 1-2期

关键词：

Azathioprine; Dendritic cells; Tolerance; CHEMOKINE RECEPTOR CCR7; MULTIPLE-SCLEROSIS; DOWN-REGULATION; AZATHIOPRINE; CD83; EXPRESSION; IL-23; CNS; MATURATION; THERAPY;

D O I：

10.1016/j.jneuroim.2009.11.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Azathioprine (Aza), 6-Mercaptopurine (6-MP) and 6-Thioguanine (6-TG) are thiopurine drugs widely used as immunosuppressants/anti-inflammatory agents in organ transplantation and chemotherapy. Aza is well tolerated and effective in modifying the course of MS. Here we investigated the action of 6-MP on human dendritic cells (DCs). We described for the first time that 6-MP impairs in vitro differentiation of DCs, has an inhibitory effect during DC activation processes inducing a functionally less immunogenic phenotype. Moreover, 6-MP significantly reduces DC IL-23 production and CCR7 expression, at the same time induces IL-10 augmentation. All these findings add a novel action mechanism in Aza immune modulation. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：28 / 35

页数：8

共 37 条

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