Phosphorylated PmrA interacts with the promoter region of ugd in Salmonella enterica serovar Typhimurium

被引：42

作者：

Aguirre, A ^{[1
]}

Lejona, S ^{[1
]}

Véscovi, EG ^{[1
]}

Soncini, FC ^{[1
]}

机构：

[1] Univ Nacl Rosario, Dept Microbiol, Fac Ciencias Bioquim & Farmaceut, RA-2000 Rosario, Santa Fe, Argentina

来源：

JOURNAL OF BACTERIOLOGY | 2000年 / 182卷 / 13期

关键词：

D O I：

10.1128/JB.182.13.3874-3876.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Salmonella PmrA-PmrB system controls the expression of genes necessary for polymyxin B resistance. Four loci were previously identified as part of the regulon, and interaction of PmrA with the promoter region of three of them was observed. Here we characterized the interaction of PmrA with the promoter region of ugd, previously suggested to be regulated indirectly by PmrA. Our results indicate that PmrA controls the expression of ugd by interacting with a specific sequence in the promoter region of this gene.

引用

页码：3874 / 3876

页数：3

共 23 条

[1] The Salmonella typhi melittin resistance gene pqaB affects intracellular growth in PMA-differentiated U937 cells, polymyxin B resistance and lipopolysaccharide
Baker, SJ
Gunn, JS
Morona, R
[J]. MICROBIOLOGY-SGM, 1999, 145 : 367 - 378
[2] In vitro reconstitution and characterization of the Rhodobacter capsulatus NtrB and NtrC two-component system
Cullen, PJ
Bowman, WC
Kranz, RG
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (11) : 6530 - 6536
[3] CHARACTERIZATION OF THE CASSETTE CONTAINING GENES FOR TYPE-3 CAPSULAR POLYSACCHARIDE BIOSYNTHESIS IN STREPTOCOCCUS-PNEUMONIAE
DILLARD, JP
VANDERSEA, MW
YOTHER, J
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (03) : 973 - 983
[4] DOUGHERTY BA, 1993, J BIOL CHEM, V268, P7118
[5] Mutational analysis of the phoD promoter in Bacillus subtilis:: Implications for PhoP binding and promoter activation of Pho regulon promoters
Eder, S
Liu, W
Hulett, FM
[J]. JOURNAL OF BACTERIOLOGY, 1999, 181 (07) : 2017 - 2025
[6] GROLSMAN EA, 1997, J BACTERIOL, V179, P4040
[7] PhoP-PhoQ activates transcription of pmrAB, encoding a two-component regulatory system involved in Salmonella typhimurium antimicrobial peptide resistance
Gunn, JS
Miller, SI
[J]. JOURNAL OF BACTERIOLOGY, 1996, 178 (23) : 6857 - 6864
[8] PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance
Gunn, JS
Lim, KB
Krueger, J
Kim, K
Guo, L
Hackett, M
Miller, SI
[J]. MOLECULAR MICROBIOLOGY, 1998, 27 (06) : 1171 - 1182
[9] Relative binding affinities of OmpR and OmpR-phosphate at the ompF and ompC regulatory sites
Head, CG
Tardy, A
Kenney, LJ
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1998, 281 (05) : 857 - 870
[10] INCREASED SUBSTITUTION OF PHOSPHATE GROUPS IN LIPOPOLYSACCHARIDES AND LIPID-A OF THE POLYMYXIN-RESISTANT PMRA MUTANTS OF SALMONELLA-TYPHIMURIUM - A P-31-NMR STUDY
HELANDER, IM
KILPELAINEN, I
VAARA, M
[J]. MOLECULAR MICROBIOLOGY, 1994, 11 (03) : 481 - 487

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