Annexin IV is Differentially Expressed in Clear Cell Carcinoma of the Ovary

被引：25

作者：

Miao, Yi ^{[1
]}

Cai, Bin ^{[1
]}

Liu, Ling ^{[1
,2
,3
]}

Yang, Yixia ^{[1
]}

Wan, Xiaoping ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Dept Obstet & Gynecol, Afiliated Peoples Hosp 1, Shanghai 200080, Peoples R China

[2] Univ Toronto, Dept Med, Toronto, ON, Canada

[3] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada

来源：

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER | 2009年 / 19卷 / 09期

关键词：

Clear cell carcinoma of the ovary; Gene expression profiling; Annexin IV; GENE-EXPRESSION; CLINICAL CHARACTERISTICS; ENDOMETRIAL CANCER; RESISTANCE; TUMORS; CLASSIFICATION; IDENTIFICATION; LYMPHOMA; PROTEINS;

D O I：

10.1111/IGC.0b013e3181a844c8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective: To investigate the genes that were differentially expressed between clear cell carcinoma (CCC) and serous carcinoma (SAC) of the ovary with complementary DNA microarray. Methods: Complementary DNA microarray was carried out in 8 CCCs and 8 SACs of the ovary. Differentially expressed genes were identified and verified by real-time polymerase chain reaction. The expression of the protein was also verified with immnunohistochemistry and Western blot in cells and tissues of ovarian CCC. Results: Comparison of the gene expression profiling identified 21 genes with more than 2-fold different expression between CCC and SAC of the ovary. The up-regulated and down-regulated genes were 9 and 12, respectively. The verification of Annexin IV in the cell line and tissues was in accordance with the result of the microarray. Conclusions: The complementary DNA microarray technique is a feasible way to explore the difference of the gene expression profiling between the 2 types of ovarian carcinoma. The overexpression of Annexin IV may be an ovarian CCC-specific molecular marker.

引用

页码：1545 / 1549

页数：5

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