The extracts of Astragalus membranaceus enhance chemosensitivity and reduce tumor indoleamine 2, 3-dioxygenase expression

被引：16

作者：

Phacharapiyangkul, Naphichaya ^{[1
]}

Wu, Li-Hsien ^{[2
]}

Lee, Wei-Ya ^{[2
]}

Kuo, Yi-Hsuan ^{[2
]}

Wu, Yueh-Jung ^{[3
]}

Liou, Huei-Pu ^{[3
]}

Tsai, Yung-En ^{[4
]}

Lee, Che-Hsin ^{[2
,5
,6
]}

机构：

[1] Mahidol Univ, Fac Pharm, Dept Microbiol, Bangkok, Thailand

[2] Natl Sun Yat Sen Univ, Dept Biol Sci, 70 Lienhai Rd, Kaohsiung 80424, Taiwan

[3] Kaohsiung Armed Forces Gen Hosp, Dept Surg, Kaohsiung, Taiwan

[4] Kaohsiung Armed Forces Gen Hosp, Dept Internal Med, Div Nephrol, Kaohsiung, Taiwan

[5] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung, Taiwan

[6] Kaohsiung Med Univ, Dept Med Lab Sci & Biotechnol, Kaohsiung, Taiwan

来源：

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2019年 / 16卷 / 08期

关键词：

Astragalus membranaceus; PG2; Connexin; 43; Indoleamine; 2; 3-dioxygenase; Combination therapy; JUNCTIONAL INTERCELLULAR COMMUNICATION; CONNEXIN-43; SALMONELLA; INHIBITION; PROTEIN; CHEMOPREVENTION; RESVERATROL; PROTECTION;

D O I：

10.7150/ijms.33106

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Astragalus membranaceus has been shown to possess anti-inflammation and antitumor properties. Several studies have indicated that extracts of Astragalus membranaceus (PG2) have growth inhibitory effects on tumor. However, the effect of PG2 on enhancing the chemotherapy, modulating tumor immune escape and their mechanism of action is unknown and need further investigation. Connexin (Cx) 43 is ubiquitous in cells and involved in facilitating the passage of chemotherapeutic drugs to bystander tumor cells. The indoleamine 2, 3-dioxygenase (IDO) depletes tryptophan, reduces the active T cell number and destroys immune surveillance. Herein, we provide evidence that the treatment of PG2 induced Cx43 expression, decreases IDO expression and enhances the distribution of chemotherapeutic drug. However, the effects of combination therapy (PG2 plus cisplatin) in animal models significantly retarded tumor growth and prolonged the survival. We believe that the information provided in this study may aid in the design of future therapy of PG2, suggest suitable combinations with chemotherapies.

引用

页码：1107 / 1115

页数：9

共 27 条

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Gap Junction Intercellular Communication Positively Regulates Cisplatin Toxicity by Inducing DNA Damage through Bystander Signaling [J].