Metal organic frameworks as NO delivery materials for biological applications

被引：180

作者：

Hinks, Nathan J. ^{[1
]}

McKinlay, Alistair C. ^{[1
]}

Xiao, Bo ^{[1
]}

Wheatley, Paul S. ^{[1
]}

Morris, Russell E. ^{[1
]}

机构：

[1] Univ St Andrews, EaStChem Sch Chem, St Andrews KY16 9ST, Fife, Scotland

来源：

MICROPOROUS AND MESOPOROUS MATERIALS | 2010年 / 129卷 / 03期

关键词：

Metal organic frameworks; Biomaterials; Nitric oxide; NITRIC-OXIDE; DRUG-DELIVERY; STORAGE; ADSORPTION; HYDROGEN; MOLECULES; SOLIDS; DONORS; WOUNDS; MIL-53;

D O I：

10.1016/j.micromeso.2009.04.031

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Metal organic frameworks (MOFs) are highly porous materials that can store significant amounts of gas, including nitric oxide. The chemical composition and toxicology of many (but not all) of these materials makes them potentially suitable for medical applications. In this paper, we will describe how triggered release methods can be used to deliver biologically relevant amounts of NO and then show how Ni, Co and Cu-containing MOFs are biologically active materials with potential applications in several different areas (anti-thrombosis, dermatology and wound healing, anti-bacterial, vasodilation etc.). We will also discuss the pros and cons of MOFs, including their chemical and biological stability and the toxicology of MOFs in general. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：330 / 334

页数：5

共 28 条

[1] Adsorption properties of HKUST-1 toward hydrogen and other small molecules monitored by IR [J].

Bordiga, S. ;

Regli, L. ;

Bonino, F. ;

Groppo, E. ;

Lamberti, C. ;

Xiao, B. ;

Wheatley, P. S. ;

Morris, R. E. ;

Zecchina, A. .

PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2007, 9 (21) :2676-2685

[2] A route to high surface area, porosity and inclusion of large molecules in crystals [J].

Chae, HK ;

Siberio-Pérez, DY ;

Kim, J ;

Go, Y ;

Eddaoudi, M ;

Matzger, AJ ;

O'Keeffe, M ;

Yaghi, OM .

NATURE, 2004, 427 (6974) :523-527

[3] A chemically functionalizable nanoporous material [Cu3(TMA)2(H2O)3]n [J].

Chui, SSY ;

Lo, SMF ;

Charmant, JPH ;

Orpen, AG ;

Williams, ID .

SCIENCE, 1999, 283 (5405) :1148-1150

[4] Ionic liquids and eutectic mixtures as solvent and template in synthesis of zeolite analogues [J].

Cooper, ER ;

Andrews, CD ;

Wheatley, PS ;

Webb, PB ;

Wormald, P ;

Morris, RE .

NATURE, 2004, 430 (7003) :1012-1016

[5] Nitric oxide-releasing fabrics and other acrylonitrile-based diazeniumdiolates [J].

DeRosa, Frank ;

Kibbe, Melina R. ;

Najjar, Samer F. ;

Citro, Michael L. ;

Keefer, Larry K. ;

Hrabie, Joseph A. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (13) :3786-+

[6] An in situ high-temperature single-crystal investigation of a dehydrated metal-organic framework compound and field-induced magnetization of one-dimensional metaloxygen chains [J].

Dietzel, PDC ;

Morita, Y ;

Blom, R ;

Fjellvåg, H .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (39) :6354-6358

[7] Systematic design of pore size and functionality in isoreticular MOFs and their application in methane storage [J].

Eddaoudi, M ;

Kim, J ;

Rosi, N ;

Vodak, D ;

Wachter, J ;

O'Keeffe, M ;

Yaghi, OM .

SCIENCE, 2002, 295 (5554) :469-472

[8] Hybrid porous solids:: past, present, future [J].

Ferey, Gerard .

CHEMICAL SOCIETY REVIEWS, 2008, 37 (01) :191-214

[9]

HORCAJADA P, 2008, 1 INT C MOFS AUGSB O

[10] Flexible porous metal-organic frameworks for a controlled drug delivery [J].

Horcajada, Patricia ;

Serre, Christian ;

Maurin, Guillaume ;

Ramsahye, Naseem A. ;

Balas, Francisco ;

Vallet-Regi, Maria ;

Sebban, Muriel ;

Taulelle, Francis ;

Ferey, Gerard .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (21) :6774-6780

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