Signaling mechanisms of vasoactive intestinal peptide in inflammatory conditions

被引：29

作者：

Chorny, Alejo ^{[1
]}

Gonzalez-Rey, Elena ^{[1
]}

Varela, Niveves ^{[1
]}

Robledo, Gerna ^{[1
]}

Delgado, Mario ^{[1
]}

机构：

[1] CSIC, Inst Parasitol & Biomed, Granada 18100, Spain

来源：

REGULATORY PEPTIDES | 2006年 / 137卷 / 1-2期

关键词：

inflammation; neuroimmunology; neuropeptide; macrophage; transcription factors;

D O I：

10.1016/j.regpep.2006.04.021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The vasoactive intestinal peptide (VIP) is a neuropeptide belonging to the secretin/glucagon family of peptides, which exerts a wide spectrum of immunological functions controlling the homeostasis of immune system through different receptors expressed in various immunocompetent cells. In the last decade, VIP has emerged as a potent anti-inflammatory factor, which exerts its function by regulating the production of both anti- and pro-inflammatory mediators, In this sense, VIP has been proposed as a promising candidate, alternative to other existing treatments, for treating acute and chronic inflammatory and autoimmune diseases, such as septic shock, rheumatoid arthritis, multiple sclerosis and Crohn's disease. The present work reviews the involvement of the specific receptors and or different transduction pathways and transcription factors in the anti- inflammatory action of VIP, and their implication on its therapeutic effect on inflammatory/autoimmune disorders. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：67 / 74

页数：8

共 57 条

[1] Therapeutic effects of vasoactive intestinal peptide in the trinitrobenzene sulfonic acid mice model of Crohn's disease
Abad, C
Martinez, C
Juarranz, MG
Arranz, A
Leceta, J
Delgado, M
Gomariz, RP
[J]. GASTROENTEROLOGY, 2003, 124 (04) : 961 - 971
[2] Mechanisms of phagocytosis in macrophages
Aderem, A
Underhill, DM
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 : 593 - 623
[3] The IFN gamma receptor: A paradigm for cytokine receptor signaling
Bach, EA
Aguet, M
Schreiber, RD
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 : 563 - &
[4] JUN-B DIFFERS IN ITS BIOLOGICAL PROPERTIES FROM, AND IS A NEGATIVE REGULATOR OF, C-JUN
CHIU, R
ANGEL, P
KARIN, M
[J]. CELL, 1989, 59 (06) : 979 - 986
[5] Vasoactive intestinal peptide induces regulatory dendritic cells with therapeutic effects on autoimmune disorders
Chorny, A
Gonzalez-Rey, E
Fernandez-Martin, A
Pozo, D
Ganea, D
Delgado, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (38) : 13562 - 13567
[6] PHOSPHORYLATED CREB BINDS SPECIFICALLY TO THE NUCLEAR-PROTEIN CBP
CHRIVIA, JC
KWOK, RPS
LAMB, N
HAGIWARA, M
MONTMINY, MR
GOODMAN, RH
[J]. NATURE, 1993, 365 (6449) : 855 - 859
[7] Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit interleukin-12 transcription by regulating nuclear factor κB and Ets activation
Delgado, M
Ganea, D
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (45) : 31930 - 31940
[8] VIP and PACAP38 modulate cytokine and nitric oxide production in peritoneal macrophages and macrophage cell lines
Delgado, M
Munoz-Elias, EJ
Martinez, C
Gomariz, RP
Ganea, D
[J]. NEUROPEPTIDES: STRUCTURE AND FUNCTION IN BIOLOGY AND BEHAVIOR, 1999, 897 : 401 - 414
[9] Vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide inhibit the MEKK1/MEK4/JNK signaling pathway in LPS-stimulated macrophages
Delgado, M
Ganea, D
[J]. JOURNAL OF NEUROIMMUNOLOGY, 2000, 110 (1-2) : 97 - 105
[10] The neuropeptide vasoactive intestinal peptide generates tolerogenic dendritic cells
Delgado, M
Gonzalez-Rey, E
Ganea, D
[J]. JOURNAL OF IMMUNOLOGY, 2005, 175 (11) : 7311 - 7324

← 1 2 3 4 5 6 →