Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis

被引：148

作者：

Ichimura, Atsuhiko ^{[1
]}

Hirasawa, Akira ^{[1
]}

Hara, Takafumi ^{[1
]}

Tsujimoto, Gozoh ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Dept Genom Drug Discovery Sci, Sakyo Ku, Kyoto 6068501, Japan

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2009年 / 89卷 / 3-4期

关键词：

G-protein-coupled receptor; Free fatty acid; Insulin; FFAR1; FFAR2; FFAR3; GPR120; PROTEIN-COUPLED-RECEPTOR; STIMULATED INSULIN-SECRETION; PANCREATIC BETA-CELLS; CHOLECYSTOKININ SECRETION; GPR40; FFAR1; RAT; ACTIVATION; AGONISTS; GPR120; IDENTIFICATION;

D O I：

10.1016/j.prostaglandins.2009.05.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Free fatty acids (FFAs) have been demonstrated to act as ligands of several G-protein-coupled receptors (GPCRs) (FFAR1, FFAR2, FFAR3, GPR84, and GPR120). These fatty acid receptors are proposed to play critical roles in a variety of types of physiological homeostasis. FFAR1 and GPR120 are activated by medium- and long-chain FFAs. GPR84 is activated by medium-chain, but not long-chain, FFAs. In contrast, FFAR2 and FFAR3 are activated by short-chain FFAs. FFAR1 is expressed mainly in pancreatic beta-cells and mediates insulin secretion, whereas GPR120 is expressed abundantly in the intestine and promotes the secretion of glucagon-like peptide-1 (GLP-1). FFAR3 is expressed in enteroendocrine cells and regulates host energy balance through effects that are dependent upon the gut microbiota. In this review, we summarize the identification, structure, and pharmacology of these receptors and present an essential overview of the current understanding of their physiological roles. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：82 / 88

页数：7

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