Low frequency sonophoresis: A noninvasive method of drug delivery and diagnostics

被引:96
作者
Mitragotri, S [1 ]
Kost, J
机构
[1] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93016 USA
[2] Sontra Med, Cambridge, MA 02141 USA
[3] Ben Gurion Univ Negev, Dept Chem Engn, IL-84105 Beer Sheva, Israel
关键词
D O I
10.1021/bp000024+
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Transdermal drug delivery offers an attractive alternative to injections and oral medications. However, applications of transdermal drug delivery are limited to only a few drugs as a result of low skin permeability. Application of low-frequency ultrasound enhances skin permeability, a phenomenon referred to as low-frequency sonophoresis. In this method, a short application of ultrasound is used to permeabilize skin for a prolonged period of time. During this period, ultrasonically permeabilized skin may be utilized for drug delivery. In addition, a sample of interstitial fluid or its components may be extracted through permeabilized skin for diagnostic applications. In this paper, we report our in vivo studies that demonstrate the principles of both of these concepts. Detailed studies on drug delivery are performed using inulin and mannitol as model drugs. Studies on diagnostics are performed using glucose as a model analyte. Applications of this technology to drug delivery and diagnostics are discussed.
引用
收藏
页码:488 / 492
页数:5
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