Neuroprotective and neurotoxic roles of levodopa (L-DOPA) in neurodegenerative disorders relating to Parkinson's disease

被引：54

作者：

Kostrzewa, RM

Kostrzewa, JP

Brus, R

机构：

[1] E Tennessee State Univ, Dept Pharmacol, Quillen Coll Med, Johnson City, TN 37614 USA

[2] Med Univ Silesia, Dept Pharmacol, Zabrze, Poland

来源：

AMINO ACIDS | 2002年 / 23卷 / 1-3期

关键词：

L-DOPA; Parkinson's disease; reactive oxygen species;

D O I：

10.1007/s00726-001-0110-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite its being the most efficacious drug for symptom reversal in Parkinson's disease (PD), there is concern that chronic levodopa (L-DOPA) treatment may be detrimental. In this paper we review the potential for L-DOPA to 1) autoxidize from a catechol to a quinone, and 2) generate other reactive oxygen species (ROS). Overt toxicity and neuroprotective effects of L-DOPA, both in vivo and in vitro, are described in the context of whether L-DOPA may accelerate or delay progression of human Parkinson's disease.

引用

页码：57 / 63

页数：7

共 92 条

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