An automated platform for parallel crystallization of small organic molecules

被引：33

作者：

Florence, Alastair J.

Johnston, Andrea

Fernandes, Philippe

Shankland, Norman

Shankland, Kenneth

机构：

[1] Univ Strathclyde, Solid State Res Grp, Strathclyde Inst Pharm & Biomed Sci, Glasgow G4 0NR, Lanark, Scotland

[2] Rutherford Appleton Lab, CCLRC, ISIS Facil, Didcot OX11 1QX, Oxon, England

来源：

JOURNAL OF APPLIED CRYSTALLOGRAPHY | 2006年 / 39卷

关键词：

D O I：

10.1107/S0021889806040921

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An automated platform for parallel crystallization of small organic molecules from solution is described. The principal gain over manual crystallization lies in the automated sequencing of crystallization steps, including computer-controlled dosing of liquids and solids. The platform is designed to conduct 32 crystallizations per day, from solution volumes up to 10 ml, allowing a search for physical forms to be conducted over a finer grid than might be accessible manually and thereby increasing the probability of success.

引用

页码：922 / 924

页数：3

共 7 条

[1]

*CHEMSP TECHN, 2006, AUT SOFTW VERS 1 5

[2] Control and prediction of packing motifs: a rare occurrence of carbamazepine in a catemeric configuration [J].

Florence, A. J. ;

Leech, C. K. ;

Shankland, N. ;

Shankland, K. ;

Johnston, A. .

CRYSTENGCOMM, 2006, 8 (10) :746-747

[3] Indexing powder patterns in physical form screening: Instrumentation and data quality [J].

Florence, AJ ;

Baumgartner, B ;

Weston, C ;

Shankland, N ;

Kennedy, AR ;

Shankland, K ;

David, WIF .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2003, 92 (09) :1930-1938

[4] An automated parallel crystallisation search for predicted crystal structures and packing motifs of carbamazepine [J].

Florence, Alastair J. ;

Johnston, Andrea ;

Price, Sarah L. ;

Nowell, Harriott ;

Kennedy, Alan R. ;

Shankland, Norman .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2006, 95 (09) :1918-1930

[5] High-throughput crystallization:: polymorphs, salts, co-crystals and solvates of phan-naceutical solids [J].

Monissette, SL ;

Almarsson, Ö ;

Peterson, ML ;

Remenar, JF ;

Read, MJ ;

Lemmo, AV ;

Ellis, S ;

Cima, MJ ;

Gardner, CR .

ADVANCED DRUG DELIVERY REVIEWS, 2004, 56 (03) :275-300

[6]

MUNSCH C, 2003, 14 CHEMSP TECHN

[7]

SCHROER J, 2003, 26 CHEMSP TECHN

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