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Platelets in atherothrombosis

被引：1288
作者：
Ruggeri, ZM [1 ]
机构：
[1] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA
来源：
NATURE MEDICINE | 2002年 / 8卷 / 11期
关键词：
D O I：
10.1038/nm1102-1227
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The participation of platelets in atherogenesis and the subsequent formation of occlusive thrombi depend on platelets' adhesive properties and the inability to respond to stimuli with rapid activation. By understanding the multifaceted mechanisms involved in platelet interaction with vascular surfaces and aggregation, new approaches can be tailored to selectively inhibit the pathways most relevant to the pathological aspects of atherothrombosis.
引用
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页码：1227 / 1234
页数：8
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