Origins and functions of phagocytes in the embryo

被引:115
作者
Lichanska, AM
Hume, DA [1 ]
机构
[1] Univ Queensland, Dept Biochem, St Lucia, Qld 4072, Australia
[2] Univ Queensland, Dept Microbiol, St Lucia, Qld 4072, Australia
[3] Univ Queensland, Ctr Cellular & Mol Biol, St Lucia, Qld 4072, Australia
[4] Queens Univ Belfast, Dept Med Genet, Belfast, Antrim, North Ireland
[5] Queens Univ Belfast, Dept Ophthalmol, Belfast, Antrim, North Ireland
关键词
macrophage; embryo; apoptosis; differentiation; yolk sac;
D O I
10.1016/S0301-472X(00)00157-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To review the data on the origins, phenotype, and function of embryonic phagocytes that has accumulated over past decade. Data Sources. Most of the relevant articles were selected based on the PubMed database entries. In additional, the Interactive Fly database (http://sdb.bio.purdue.edu/fly/aimain/ 1aahome.htm), FlyBase (http://flybase.bio.indiana.edu:82/), and TBase (http://tbase.jax.org/) were used to search for relevant information and articles. Data Synthesis. Phagocytes in a vertebrate embryo develop in two sites (yolk sac and liver) and contribute to organogenesis in part through their ability to recognize and clear apoptotic cells. Yolk sac-derived phagocytes differ in differentiation pathway and marker gene expression from macrophages produced via classic hematopoietic progenitors in the liver. Conclusion, We argue that yolk sac-derived phagocytes constitute a separate cell lineage. This conclusion raises the question of whether primitive phagocytes persist into the adulthood. (C) 2000 International Society for Experimental Hematology. Published by Elsevier Science Inc.
引用
收藏
页码:601 / 611
页数:11
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