T-cell signaling: The importance of receptor clustering

被引：102

作者：

Germain, RN

机构：

来源：

CURRENT BIOLOGY | 1997年 / 7卷 / 10期

关键词：

D O I：

10.1016/S0960-9822(06)00323-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

T-cell receptors bound to peptide-MHC molecules undergo higher-order oligomerization in solution. This observation, the low-affinity-recognition properties of T-cell receptors, and other indications that such receptors undergo rapid, serial engagement by a single ligand suggest a dynamic clustering model of T-cell signaling. (C) Current Biology Ltd ISSN 0960-9822.

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页码：R640 / R644

页数：5

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