T-cell signaling: The importance of receptor clustering

被引:102
作者
Germain, RN
机构
关键词
D O I
10.1016/S0960-9822(06)00323-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
T-cell receptors bound to peptide-MHC molecules undergo higher-order oligomerization in solution. This observation, the low-affinity-recognition properties of T-cell receptors, and other indications that such receptors undergo rapid, serial engagement by a single ligand suggest a dynamic clustering model of T-cell signaling. (C) Current Biology Ltd ISSN 0960-9822.
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页码:R640 / R644
页数:5
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