Proteases in host cell invasion by the malaria parasite

被引:39
作者
Blackman, MJ [1 ]
机构
[1] Natl Inst Med Res, Div Parasitol, London NW7 1AA, England
关键词
D O I
10.1111/j.1462-5822.2004.00437.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The life cycle of the malaria parasite contains three distinct invasive forms, or zoites. For at least two of these - the sporozoite and the blood-stage merozoite - invasion into their respective host cell requires the activity of parasite proteases. This review summarizes the evidence for this, discusses selected well-described proteolytic modifications linked to invasion, and describes recent progress towards identifying the proteases involved.
引用
收藏
页码:893 / 903
页数:11
相关论文
共 97 条
[1]   Analysis of the Plasmodium and Anopheles transcriptional repertoire during ookinete development and midgut invasion [J].
Abraham, EG ;
Islam, S ;
Srinivasan, P ;
Ghosh, AK ;
Valenzuela, JG ;
Ribeiro, JMC ;
Kafatos, FC ;
Dimopoulos, G ;
Jacobs-Lorena, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (07) :5573-5580
[2]   An expanding ebl family of Plasmodium falciparum [J].
Adams, JH ;
Blair, PL ;
Kaneko, O ;
Peterson, DS .
TRENDS IN PARASITOLOGY, 2001, 17 (06) :297-299
[3]   THE DUFFY RECEPTOR FAMILY OF PLASMODIUM-KNOWLESI IS LOCATED WITHIN THE MICRONEMES OF INVASIVE MALARIA MEROZOITES [J].
ADAMS, JH ;
HUDSON, DE ;
TORII, M ;
WARD, GE ;
WELLEMS, TE ;
AIKAWA, M ;
MILLER, LH .
CELL, 1990, 63 (01) :141-153
[4]   Development and pre-clinical analysis of a Plasmodium falciparum Merozoite Surface Protein-142 malaria vaccine [J].
Angov, E ;
Aufiero, BM ;
Turgeon, AM ;
Van Handenhove, M ;
Ockenhouse, CF ;
Kester, KE ;
Walsh, DS ;
McBride, JS ;
Dubois, MC ;
Cohen, J ;
Haynes, JD ;
Eckels, KH ;
Heppner, DG ;
Ballou, WR ;
Diggs, CL ;
Lyon, JA .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2003, 128 (02) :195-204
[5]   Serine repeat antigen (SERA5) is predominantly expressed among the SERA multigene family of Plasmodium falciparum, and the acquired antibody titers correlate with serum inhibition of the parasite growth [J].
Aoki, S ;
Li, J ;
Itagaki, S ;
Okech, BA ;
Egwang, TG ;
Matsuoka, H ;
Palacpac, NMQ ;
Mitamura, T ;
Horii, T .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (49) :47533-47540
[6]   STRUCTURE AND INVASIVE BEHAVIOR OF PLASMODIUM-KNOWLESI MEROZOITES INVITRO [J].
BANNISTER, LH ;
BUTCHER, GA ;
DENNIS, ED ;
MITCHELL, GH .
PARASITOLOGY, 1975, 71 (DEC) :483-&
[7]   A brief illustrated guide to the ultrastructure of Plasmodium falciparum asexual blood stages [J].
Bannister, LH ;
Hopkins, JM ;
Fowler, RE ;
Krishna, S ;
Mitchell, GH .
PARASITOLOGY TODAY, 2000, 16 (10) :427-433
[8]   Plasmodium falciparum apical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite development [J].
Bannister, LH ;
Hopkins, JM ;
Dluzewski, AR ;
Margos, G ;
Williams, IT ;
Blackman, MJ ;
Kocken, CH ;
Thomas, AW ;
Mitchell, GH .
JOURNAL OF CELL SCIENCE, 2003, 116 (18) :3825-3834
[9]   Plasmodium falciparum subtilisin-like protease 2, a merozoite candidate for the merozoite surface protein 1-42 maturase [J].
Barale, JC ;
Blisnick, T ;
Fujioka, H ;
Alzari, PM ;
Aikawa, M ;
Braun-Breton, C ;
Langsley, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (11) :6445-6450
[10]  
Blackman Michael J., 2000, Current Drug Targets, V1, P59, DOI 10.2174/1389450003349461