8-hydroxydihydrochelerythrine and 8-hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L.

被引：62

作者：

Cho, Kyung-Mi ^{[1
]}

Yoo, Ick-Dong ^{[1
]}

Kim, Won-Gon ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Taejon 305600, South Korea

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2006年 / 29卷 / 11期

关键词：

Chelidonium majus L; acetylcholinesterase; 8-hydroxydihydrochelerythrine; 8-hydroxydihydrosanguinarine;

D O I：

10.1248/bpb.29.2317

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Ethanol extract of the aerial portion of Chelidonium majus L. inhibited acetylcholinesterase (ACNE) activity without a significant inhibition of butyrylcholinesterase (BuChE). Using mass spectrometry and NMR studies, three active constituents were isolated and identified: 8-hydroxydihydrochelerythrine (1), 8-hydroxydihydrosan-guinarine (2), and berberine (3). Compounds 1-3 showed potent inhibitory activity against ACNE, with IC50 (mu m) values of 0.61-1.85. Compound 1 exhibited competitive and selective inhibition for AChE.

引用

页码：2317 / 2320

页数：4

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