Treating muscular dystrophy with stem cells?

被引:31
作者
Davies, Kay E. [1 ]
Grounds, Miranda D.
机构
[1] Univ Oxford, MRC Funct Genet Unit, Oxford, England
[2] Univ Western Australia, Sch Anat & Human Biol, Nedlands, WA 6009, Australia
关键词
D O I
10.1016/j.cell.2006.12.010
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
There is currently no effective treatment for the devastating muscle-wasting disease Duchenne muscular dystrophy (DMD). Cossu and colleagues report in a recent Nature paper that transplantation of mesoangioblast stem cells may hold promise for treating DMD. Further studies are required to fully evaluate the clinical potential of these blood-vessel-associated stem cells.
引用
收藏
页码:1304 / 1306
页数:3
相关论文
共 11 条
[1]   A multidisciplinary evaluation of the effectiveness of cyclosporine A in dystrophic Mdx mice [J].
De Luca, A ;
Nico, B ;
Liantonio, A ;
Didonna, MP ;
Fraysse, B ;
Pierno, S ;
Burdi, R ;
Mangieri, D ;
Rolland, JF ;
Camerino, C ;
Zallone, A ;
Confalonieri, P ;
Andreetta, F ;
Arnoldi, E ;
Courdier-Fruh, I ;
Magyar, JP ;
Frigeri, A ;
Pisoni, M ;
Svelto, M ;
Camerino, DC .
AMERICAN JOURNAL OF PATHOLOGY, 2005, 166 (02) :477-489
[2]  
Galvez BG, 2006, J CELL BIOL, V174, P231, DOI 10.1083/jcb.200512085
[3]   Muscle-derived stem cells: Implications for effective myoblast transfer therapy [J].
Lee-Pullen, TF ;
Grounds, MD .
IUBMB LIFE, 2005, 57 (11) :731-736
[4]  
Miller RG, 1997, MUSCLE NERVE, V20, P469, DOI 10.1002/(SICI)1097-4598(199704)20:4<469::AID-MUS10>3.0.CO
[5]  
2-U
[6]   MyoD expression restores defective myogenic differentiation of human mesoangioblasts from inclusion-body myositis muscle [J].
Morosetti, Roberta ;
Mirabella, Massimiliano ;
Gliubizzi, Carla ;
Broccolini, Aldobrando ;
De Angelis, Luciana ;
Tagliafico, Enrico ;
Sampaolesi, Maurilio ;
Gidaro, Teresa ;
Papacci, Manuela ;
Roncaglia, Enrica ;
Rutella, Sergio ;
Ferrari, Stefano ;
Tonali, Pietro Attilio ;
Ricci, Enzo ;
Cossu, Giulio .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (45) :16995-17000
[7]   Duchenne muscular dystrophy and dystrophin: pathogenesis and opportunities for treatment - Third in Molecular Medicine Review Series [J].
Nowak, KJ ;
Davies, KE .
EMBO REPORTS, 2004, 5 (09) :872-876
[8]  
RADLEY H, 2006, INT J BIOCHEM CELL B, DOI DOI 10.1016/BIOCEL.2006.09.009
[9]   Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs [J].
Sampaolesi, Maurilio ;
Blot, Stephane ;
D'Antona, Giuseppe ;
Granger, Nicolas ;
Tonlorenzi, Rossana ;
Innocenzi, Anna ;
Mognol, Paolo ;
Thibaud, Jean-Laurent ;
Galvez, Beatriz G. ;
Barthelemy, Ines ;
Perani, Laura ;
Mantero, Sara ;
Guttinger, Maria ;
Pansarasa, Orietta ;
Rinaldi, Chiara ;
De Angelis, M. Gabriella Cusella ;
Torrente, Yvan ;
Bordignon, Claudio ;
Bottinelli, Roberto ;
Cossu, Giulio .
NATURE, 2006, 444 (7119) :574-579
[10]   CYCLOSPORINE INCREASES MUSCULAR FORCE GENERATION IN DUCHENNE MUSCULAR-DYSTROPHY [J].
SHARMA, KR ;
MYNHIER, MA ;
MILLER, RG .
NEUROLOGY, 1993, 43 (03) :527-532