Efficient routine production of the 18F-labelled amino acid O-(2-[18F]fluoroethyl)-L-tyrosine

被引：201

作者：

Hamacher, K ^{[1
]}

Coenen, HH ^{[1
]}

机构：

[1] Forschungszentrum Julich, Inst Nukl Chem, D-52425 Julich, Germany

来源：

APPLIED RADIATION AND ISOTOPES | 2002年 / 57卷 / 06期

关键词：

O-(2-[F-18]fluoroethyl)-L-tyrosine; FET; nucleophilic F-18-fluorination;

D O I：

10.1016/S0969-8043(02)00225-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A convenient remotely controlled no-carrier-added synthesis of enantiomerically pure O-(2-[F-18]fluoroethyl)-L-tyrosine (FET) is described. This allows the distribution of the radiotracer to other laboratories according to the satellite concept. The radiochemical yield obtained within 80 min is about 60%. The FET containing HPLC fraction can be used immediately (after adding sodium chloride) for human application. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：853 / 856

页数：4

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