Susceptibility and bactericidal activity of 8 oral quinolones against conventional-fluoroquinolone-resistant Streptococcus pneumoniae clinical isolates

被引：15

作者：

Yokota, Shin-ichi ^{[1
]}

Ohkoshi, Yasuo ^{[1
]}

Fujii, Nobuhiro ^{[1
]}

机构：

[1] Sapporo Med Univ, Sch Med, Dept Microbiol, Chuo Ku, Sapporo, Hokkaido 0608556, Japan

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2009年 / 65卷 / 01期

关键词：

Streptococcus pneumoniae; Quinolones; Antibiotic resistance; PK/PD; Respiratory tract infection; RESPIRATORY-TRACT INFECTIONS; IN-VITRO; GARENOXACIN BMS-284756; PHARMACODYNAMICS; DES-F(6)-QUINOLONE; STRAINS;

D O I：

10.1016/j.diagmicrobio.2009.05.006

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

We evaluated the pharmacokinetic/pharmacodynamic parameters of 8 oral quinolones (ciprofloxacin, garenoxacin [GRNX], gatifloxacin, levofloxacin, moxifloxacin, prulifloxacin, sitafloxacin, and sparfloxacin) on 11 fluoroquinolone-resistant Streptococcus pneumoniae strains, screened from 780 strains isolated from various clinical sources in Japan. GRNX showed the highest area under the blood concentration time curve/MIC ratios, which exceeded the target values for bacterial eradication against all fluoroquinolone-resistant S. pneumoniae strains. (C) 2009 Elsevier Inc. All rights reserved,

引用

页码：76 / 80

页数：5

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