GA2LEN skin test study I: GA⊃LEN harmonization of skin prick testing: novel sensitization patterns for inhalant allergens in Europe

被引：308

作者：

Heinzerling, L. M.

Burbach, G. J.

Edenharter, G.

Bachert, C. ^{[2
]}

Bindslev-Jensen, C. ^{[3
]}

Bonini, S. ^{[4
]}

Bousquet, J. ^{[5
]}

Bousquet-Rouanet, L. ^{[5
]}

Bousquet, P. J. ^{[5
]}

Bresciani, M. ^{[4
]}

Bruno, A. ^{[6
]}

Burney, P. ^{[7
]}

Canonica, G. W. ^{[8
]}

Darsow, U. ^{[9
,10
]}

Demoly, P. ^{[5
]}

Durham, S. ^{[11
]}

Fokkens, W. J. ^{[12
]}

Giavi, S. ^{[13
]}

Gjomarkaj, M. ^{[6
]}

Gramiccioni, C. ^{[4
]}

Haahtela, T. ^{[14
]}

Kowalski, M. L. ^{[15
]}

Magyar, P. ^{[16
]}

Murakozi, G. ^{[16
]}

Orosz, M. ^{[16
]}

Papadopoulos, N. G. ^{[13
]}

Rohnelt, C.

Stingl, G. ^{[17
]}

Todo-Bom, A. ^{[18
]}

von Mutius, E. ^{[19
]}

Wiesner, A. ^{[20
]}

Wohrl, S. ^{[17
]}

Zuberbier, T. ^{[1
]}

机构：

[1] Charite, Dept Dermatol & Allergy, Allergy Ctr, D-10117 Berlin, Germany

[2] Ghent Univ Hosp, Dept Otorhinolaryngol, B-9000 Ghent, Belgium

[3] Odense Univ Hosp, Allergy Ctr, DK-5000 Odense, Denmark

[4] CNR, Rome, Italy

[5] Univ Hosp, Montpellier, France

[6] CNR, Palermo, Italy

[7] Univ London Imperial Coll Sci Technol & Med, London, England

[8] Univ Genoa, Genoa, Italy

[9] Tech Univ Munich, Dept Dermatol & Allergy Biederstein, Helmholtz Ctr, Munich, Germany

[10] Tech Univ Munich, Div Environm Dermatol & Allergy, Helmholtz Ctr, Munich, Germany

[11] Royal Brompton Hosp, Dept Resp Med, London SW3 6LY, England

[12] Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol, NL-1105 AZ Amsterdam, Netherlands

[13] Natl & Kapodistrian Univ Athens, Pediat Clin 2, Dept Allergy, Athens 11528, Greece

[14] Univ Cent Hosp, Skin & Allergy Hosp, Helsinki, Finland

[15] Med Univ Lodz, Dept Clin Immunol & Allergy, Lodz, Poland

[16] Semmelweis Univ, H-1085 Budapest, Hungary

[17] Med Univ Vienna, Dept Dermatol, Vienna, Austria

[18] Univ Coimbra, Coimbra, Portugal

[19] Univ Munich, Munich, Germany

[20] Childrens Univ Hosp, Zurich, Switzerland

来源：

ALLERGY | 2009年 / 64卷 / 10期

关键词：

allergic rhinitis; asthma; atopic dermatitis; food allergy; standardization; surveillance; CROSS-REACTIVITY; COMMON ALLERGENS; PREVALENCE; DISEASES; ASTHMA; ASSOCIATION; SYMPTOMS; CHILDREN; POLLEN; ADULTS;

D O I：

10.1111/j.1398-9995.2009.02093.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Skin prick testing is the standard for diagnosing IgE-mediated allergies. However, different allergen extracts and different testing procedures have been applied by European allergy centres. Thus, it has been difficult to compare results from different centres or studies across Europe. It was, therefore, crucial to standardize and harmonize procedures in allergy diagnosis and treatment within Europe. Aims: The Global Asthma and Allergy European Network (GA superset of LEN), with partners and collaborating centres across Europe, was in a unique position to take on this task. The current study is the first approach to implement a standardized procedure for skin prick testing in allergies against inhalant allergens with a standardized pan-European allergen panel. Methods: The study population consisted of patients who were referred to one of the 17 participating centres in 14 European countries (n = 3034, median age = 33 years). Skin prick testing and evaluation was performed with the same 18 allergens in a standardized procedure across all centres. Results: The study clearly shows that many allergens previously regarded as untypical for some regions in Europe have been underestimated. This could partly be related to changes in mobility of patients, vegetation or climate in Europe. Conclusion: The results of this large pan-European study demonstrate for the first time sensitization patterns for different inhalant allergens in patients across Europe. The standardized skin prick test with the standardized allergen battery should be recommended for clinical use and research. Further EU-wide monitoring of sensitization patterns is urgently needed.

引用

页码：1498 / 1506

页数：9

共 35 条

[1] Early, current and past pet ownership: associations with sensitization, bronchial responsiveness and allergic symptoms in school children [J].

Anyo, G ;

Brunekreef, B ;

de Meer, G ;

Aarts, F ;

Janssen, NAH ;

van Vliet, P .

CLINICAL AND EXPERIMENTAL ALLERGY, 2002, 32 (03) :361-366

[2] Sensitization to common allergens and its association with allergic disorders at age 4 years: A whole population birth cohort study [J].

Arshad, SH ;

Tariq, SM ;

Matthews, S ;

Hakim, E .

PEDIATRICS, 2001, 108 (02) :art. no.-e33

[3] INTERNATIONAL STUDY OF ASTHMA AND ALLERGIES IN CHILDHOOD (ISAAC) - RATIONALE AND METHODS [J].

ASHER, MI ;

KEIL, U ;

ANDERSON, HR ;

BEASLEY, R ;

CRANE, J ;

MARTINEZ, F ;

MITCHELL, EA ;

PEARCE, N ;

SIBBALD, B ;

STEWART, AW ;

STRACHAN, D ;

WEILAND, SK ;

WILLIAMS, HC .

EUROPEAN RESPIRATORY JOURNAL, 1995, 8 (03) :483-491

[4] Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema:: ISAAC [J].

Beasley, R ;

Keil, U ;

von Mutius, E ;

Pearce, N ;

Aït-Khaled, N ;

Anabwani, G ;

Anderson, HR ;

Asher, MI ;

Björkstéin, B ;

Burr, ML ;

Clayton, TO ;

Crane, J ;

Ellwood, P ;

Lai, CKW ;

Mallol, J ;

Martinez, FD ;

Mitchell, EA ;

Montefort, S ;

Robertson, CF ;

Shah, JR ;

Sibbald, B ;

Stewart, AW ;

Strachan, DP ;

Weiland, SK ;

Williams, HC .

LANCET, 1998, 351 (9111) :1225-1232

[5]

Bernstein IL, 1995, ANN ALLERG ASTHMA IM, V75, P543

[6] ALLERGY IN THE MEDITERRANEAN AREA .3. CROSS-REACTIVITY AMONG OLEACEAE POLLENS [J].

BOUSQUET, J ;

GUERIN, B ;

HEWITT, B ;

LIM, S ;

MICHEL, FB .

CLINICAL ALLERGY, 1985, 15 (05) :439-448

[7] THE EUROPEAN-COMMUNITY-RESPIRATORY-HEALTH-SURVEY [J].

BURNEY, PGJ ;

LUCZYNSKA, C ;

CHINN, S ;

JARVIS, D ;

VERMEIRE, P ;

DAHL, R ;

NIELSEN, N ;

MAGNUSSEN, H ;

WICHMANN, H ;

PAPAGEORGIOU, N ;

ANTO, J ;

CAPELASTEGUI, A ;

CASTILLO, J ;

MALDONADO, J ;

MORATALLA, J ;

QUIROS, R ;

BOUSQUET, J ;

NEUKIRCH, F ;

PIN, I ;

TAYTARD, A ;

TECULESCU, D ;

PRICHARD, J ;

BUGIANI, M ;

DEMARCO, R ;

CASCIO, VL ;

RIJCKEN, B ;

AVILA, R ;

LOUREIRO, C ;

MARQUES, A ;

BURR, M ;

HALL, R ;

HARRISON, B ;

STARK, J ;

FLOREY, C ;

POPP, W ;

GISLASON, T ;

GULSVIK, A ;

ACKERMANNLIEBRICH, U ;

LINDHOLM, N ;

BOMAN, G ;

ROSENHALL, L ;

AITKHALED, N ;

ABRAMSON, M ;

MANFREDA, J ;

CHOWGULE, R ;

CRANE, J ;

STEPANOV, I ;

BUIST, S .

EUROPEAN RESPIRATORY JOURNAL, 1994, 7 (05) :954-960

[8] CHILDHOOD ASTHMA IN 4 COUNTRIES - A COMPARATIVE SURVEY [J].

BURR, ML ;

LIMB, ES ;

ANDRAE, S ;

BARRY, DMJ ;

NAGEL, F .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 1994, 23 (02) :341-347

[9] THE SKIN PRICK TEST IN THE DIAGNOSIS OF ATOPIC ALLERGY [J].

DREBORG, S .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1989, 21 (04) :820-821

[10]

Dreborg S., 1989, Allergy, V44, P1

← 1 2 3 4 →