Hexafluoroacetone as protection and activation reagent in amino acid and peptide chemistry.: Regiospecific α-functionalization of aspartic acid

被引：14

作者：

Burger, K ^{[1
]}

Lange, T ^{[1
]}

Rudolph, M ^{[1
]}

机构：

[1] Univ Leipzig, Dept Organ Chem, D-04103 Leipzig, Germany

来源：

HETEROCYCLES | 2003年 / 59卷 / 01期

关键词：

D O I：

10.3987/COM-02-S17

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient method for regiospecific alpha-functionalization of aspartic acid is described. Key step is the synthesis of a N-protected and regioselectively alpha-carboxy-activated heterocyclic intermediate from aspartic acid and hexafluoroacetone. The new strategy offers La. a two step access to the sweetener Aspartame(R) and to libraries of aspartame analogues.

引用

页码：189 / 198

页数：10

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