Ipilimumab-Induced Hypophysitis: MR Imaging Findings

被引：85

作者：

Carpenter, K. J. ^{[2
]}

Murtagh, R. D. ^{[1
,2
,3
]}

Lilienfeld, H. ^{[4
]}

Weber, J. ^{[5
]}

Murtagh, F. R. ^{[1
,2
,3
]}

机构：

[1] Univ Diagnost Inst, Tampa, FL 33629 USA

[2] Univ S Florida, Dept Radiol, Tampa, FL USA

[3] H Lee Moffitt Canc Ctr & Res Inst, Dept Diagnost Imaging & Interdisciplinary Oncol, Tampa, FL USA

[4] H Lee Moffitt Canc Ctr & Res Inst, Dept Endocrinol, Tampa, FL USA

[5] H Lee Moffitt Canc Ctr & Res Inst, Dept Cutaneous Surg, Tampa, FL USA

来源：

AMERICAN JOURNAL OF NEURORADIOLOGY | 2009年 / 30卷 / 09期

关键词：

DYNAMIC MR; DIABETES-INSIPIDUS; PITUITARY;

D O I：

10.3174/ajnr.A1623

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Ipilimumab is a promising new immunotherapeutic antineoplastic agent with clinical activity in the treatment of metastatic melanoma and renal cell carcinoma. With advances in immunotherapy, however, a host of new side effects related to the mechanism of action of these drugs has appeared. At our institution, 3 patients presented with hypophysitis, which was attributed to an autoimmune process based on the documented relationship of the drug to other autoimmune phenomena and significant and rapid improvement with discontinuation of the drug and addition of steroids. We present the imaging findings in 3 patients with presumed ipilimumab-induced hypophysitis.

引用

页码：1751 / 1753

页数：3

共 10 条

[1]

LYMPHOCYTIC ADENOHYPOPHYSITIS - CONTRAST-ENHANCED MR-IMAGING IN 5 CASES [J].