An ion conductor that recognizes osmotically-stressed phospholipid bilayers

被引：24

作者：

Bandyopadhyay, P ^{[1
]}

Regen, SL ^{[1
]}

机构：

[1] Lehigh Univ, Dept Chem, Bethlehem, PA 18015 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 38期

关键词：

D O I：

10.1021/ja026895s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A synthetic ion conductor (1), derived from cholic acid and spermine, has been found capable of recognizing osmotic stress in liposomes made from 1,2-dipalmitoleoyl-sn-glycero-3-phosphocholine [(C16:1)PC]. Thus, when large unilamellar vesicles of (C16:1)PC are placed under hypotonic conditions, the Na+/Li+ transport activity of 1 increases by as much as 1 order of magnitude, relative to isotonic conditions Copyright © 2002 American Chemical Society.

引用

页码：11254 / 11255

页数：2

共 7 条

[1] Ion conductors derived from cholic acid and spermine:: Importance of facial hydrophilicity on Na+ transport and membrane selectivity [J].