Chromosome segregation and cancer: Cutting through the mystery

被引：318

作者：

Jallepalli, PV ^{[1
]}

Lengauer, C ^{[1
]}

机构：

[1] Johns Hopkins Oncol Ctr, Baltimore, MD 21231 USA

来源：

NATURE REVIEWS CANCER | 2001年 / 1卷 / 02期

关键词：

D O I：

10.1038/35101065

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mitosis is the most dramatic - and potentially dangerous - event in the cell cycle, as sister chromatids are irreversibly segregated to daughter cells. Defects in the checkpoints that normally maintain the fidelity of this process can lead to chromosomal instability (CIN) and cancer However, CIN - a driving force of tumorigenesis - could be the cancer cell's ultimate vulnerability. An important goal is to identify novel anticancer compounds that directly target the mitotic errors at the heart of CIN.

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页码：109 / 117

页数：9

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