Disease induction by human microbial pathogens in plant-model systems: potential, problems and prospects

被引:14
作者
van Baarlen, Peter
van Belkum, Alex
Thomma, Bart P. H. J.
机构
[1] Radboud Univ Nijmegen, Nijmegen Med Ctr, Nijmegen Ctr Mol Life Sci, NL-6525 GA Nijmegen, Netherlands
[2] Univ Rotterdam, Erasmus MC, Med Ctr, Dept Med Microbiol & Infect Dis, NL-3015 GD Rotterdam, Netherlands
[3] Wageningen Univ, Lab Phytopathol, NL-6709 PD Wageningen, Netherlands
关键词
D O I
10.1016/j.drudis.2006.12.007
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Relatively simple eukaryotic model organisms such as the genetic model weed plant Arabidopsis thaliana possess an innate immune system that shares important similarities with its mammalian counterpart. In fact, some human pathogens infect Arabidopsis and cause overt disease with human symptomology. In such cases, decisive elements of the plant's immune system are likely to be targeted by the same microbial factors that are necessary for causing disease in humans. These similarities can. be exploited to identify elementary microbial pathogenicity factors and their corresponding targets in a green host. This circumvents important cost aspects that often frustrate studies in humans or animal models and, in addition, results in facile ethical clearance.
引用
收藏
页码:167 / 173
页数:7
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