Sox genes find their feet

被引：430

作者：

Pevny, LH

LovellBadge, R

机构：

[1] Laboratory of Developmental Genetics, MRC Natl. Inst. for Medical Research, The Ridgeway, London NW7 1AA, Mill Hill

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1997年 / 7卷 / 03期

关键词：

D O I：

10.1016/S0959-437X(97)80147-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The identification of the mammalian testis-determining factor, SRY, led to the description of a new class of genes encoding transcription factors, the SOX gene family. SOX proteins display properties of both classical transcription factors and architectural components of chromatin. The dynamic and diverse patterns of expression of SOX genes and analysis of mutations in humans, mice and Drosophila suggest that SOX factors play key roles in decisions of cell fate during diverse developmental processes.

引用

页码：338 / 344

页数：7

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