The classification of skin irritants by human patch test

被引:73
作者
Basketter, DA [1 ]
Chamberlain, M [1 ]
Griffiths, HA [1 ]
Rowson, M [1 ]
Whittle, E [1 ]
York, M [1 ]
机构
[1] UNILEVER RES, STAT GRP, COLWORTH HOUSE, SHARNBROOK MK44 1LQ, BEDS, ENGLAND
关键词
D O I
10.1016/S0278-6915(97)00053-7
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
The human 4 hour patch test provides an opportunity to identify substances with significant skin irritation potential without recourse to the use of animals. The protocol is designed to avoid the production of more than mild irritant reactions and meets the highest ethical standards. This paper provides the background to the development of the method and comments on its performance in the light of recent intra-and inter-laboratory investigations. In particular, the value of the method in providing 'gold standard' data for the identification of those substances (or preparations) which should, or should not, be classified as irritant to skin in European legislation is discussed. On the basis of the published data and supplementary investigations, recommendations are made on both the conduct and interpretation of the human 4 hour patch test. Finally, the lack of any necessity for formal validation of this assay is addressed. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:845 / 852
页数:8
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