Genetic and environmental contributions to depression symptomatology: Evidence from Danish twins 75 years of age and older

被引:90
作者
McGue, M
Christensen, K
机构
[1] ODENSE UNIV,SCH MED,CTR HLTH & SOCIAL POLICY,ODENSE,DENMARK
[2] DANISH EPIDEMIOL SCI CTR,AARHUS,DENMARK
[3] UNIV MINNESOTA,DEPT PSYCHOL,MINNEAPOLIS,MN 55455
关键词
D O I
10.1037/0021-843X.106.3.439
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
The heritability symptoms of depression were investigated in a sample of 406 same-sex Danish twin pairs 75 years of age and older. Twins completed an interview assessment that included symptoms of depression, which were scored on the following 3 scales: Somatic, Affect, and Total. Heritability estimates (h(2)) for the Total (h(2) =.34), Somatic (h(2) =.31), and Affect (h(2) =.27) scales were all moderate and statistically significant. For not one of the scales did h(2) vary significantly over the age range sampled, and although the observed twin correlations were substantially smaller among men as compared with women, none of the sex differences in heritability were statistically significant. Multivariate analyses indicated that all of the heritable effects on the Affect and Somatic subscales could be attributed to a single genetic factor. Depression symptoms in older adults may thus be more heritable than indicated in previous studies, although nonshared environmental factors clearly account for a majority of the variance. The implications of these findings for understanding the nature of late-life depression symptomatology are discussed.
引用
收藏
页码:439 / 448
页数:10
相关论文
共 42 条
[1]   DEPRESSION AND PHYSICAL ILLNESS - A MULTIWAVE, NONRECURSIVE CAUSAL MODEL [J].
ANESHENSEL, CS ;
FRERICHS, RR ;
HUBA, GJ .
JOURNAL OF HEALTH AND SOCIAL BEHAVIOR, 1984, 25 (04) :350-371
[2]  
[Anonymous], 1973, B INT STAT I
[3]   DEPRESSIVE SYMPTOMS IN RELATION TO PHYSICAL HEALTH AND FUNCTIONING IN THE ELDERLY [J].
BERKMAN, LF ;
BERKMAN, CS ;
KASL, S ;
FREEMAN, DH ;
LEO, L ;
OSTFELD, AM ;
CORNONIHUNTLEY, J ;
BRODY, JA .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1986, 124 (03) :372-388
[4]  
BLAZER D, 1980, AM J PSYCHIAT, V137, P439
[5]  
Blazer D, 1989, Annu Rev Gerontol Geriatr, V9, P197
[6]  
CHRISTENSEN K, 1997, UNPUB DANISH POPULAT
[7]   RECLASSIFICATION OF DEPRESSION IN THE MEDICALLY ILL ELDERLY [J].
FOGEL, BS ;
FRETWELL, M .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1985, 33 (06) :446-448
[8]   IMPORTANCE OF SHARED GENES AND SHARED ENVIRONMENTS FOR SYMPTOMS OF DEPRESSION IN OLDER ADULTS [J].
GATZ, M ;
PEDERSEN, NL ;
PLOMIN, R ;
NESSELROADE, JR ;
MCCLEARN, GE .
JOURNAL OF ABNORMAL PSYCHOLOGY, 1992, 101 (04) :701-708
[9]   ARE OLD-PEOPLE MORE DEPRESSED - CROSS-SECTIONAL DATA ON CENTER FOR EPIDEMIOLOGIC STUDIES DEPRESSION SCALE FACTORS [J].
GATZ, M ;
HURWICZ, ML .
PSYCHOLOGY AND AGING, 1990, 5 (02) :284-290
[10]   THE PREVALENCE OF DEPRESSION IN A COHORT OF THE VERY ELDERLY [J].
GIRLING, DM ;
BARKLEY, C ;
PAYKEL, ES ;
GEHLHAAR, E ;
BRAYNE, C ;
GILL, C ;
MATHEWSON, D ;
HUPPERT, FA .
JOURNAL OF AFFECTIVE DISORDERS, 1995, 34 (04) :319-329