BIT, an immune antigen receptor-like molecule in the brain

被引:74
作者
Sano, S
Ohnishi, H
Omori, A
Hasegawa, J
Kubota, M
机构
[1] Mitsubishi Kasei Inst. of Life Sci., Machida, Tokyo 194
关键词
immunoglobulin superfamily; immune antigen receptor-like molecule; tyrosine phosphorylation; neurite extension; rat brain;
D O I
10.1016/S0014-5793(97)00724-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We previously found a brain-specific glycoprotein in the rat brain. It postnatally increases and is rich in the mature brain, We cloned cDNA of this protein, It is composed of a signal peptide, a V-type immunoglobulin domain, two C1-type immunoglobulin domains, a transmembrane segment and a cytoplasmic region containing two tyrosine-based activation motifs (TAM) that are variants of the antigen receptor signaling motifs, The overall structure is similar to those of immune antigen receptors, This molecule, BIT (brain immunoglobulin-like molecule with TAMs), is a major endogenous substrates of brain tyrosine kinases in vitro, Cerebral cortical neurons could extend their neurites on BIT-coated substrate and anti-Err monoclonal antibody specifically inhibited the effect, These findings and our recent study concerning BIT signal transduction mechanism suggest that BIT, an immune antigen receptor-like molecule of the brain, functions as a membrane signaling molecule that may participate in cell-cell interaction. (C) 1997 Federation of European Biochemical Societies.
引用
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页码:327 / 334
页数:8
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