Ischemic heart diseases: Current treatments and future

被引：89

作者：

Choi, Donghoon ^{[2
]}

Hwang, Ki-Chul ^{[2
]}

Lee, Kuen Yong ^{[1
]}

Kim, Yong-Hee ^{[1
]}

机构：

[1] Hanyang Univ, Dept Bioengn, Seoul 133791, South Korea

[2] Yonsei Univ, Yonsei Cardiovasc Res Inst, Yonsei Cardiovasc Hosp, Div Cardiol,Coll Med, Seoul 120749, South Korea

来源：

JOURNAL OF CONTROLLED RELEASE | 2009年 / 140卷 / 03期

关键词：

Ischemic heart disease; Percutaneous coronary intervention; Protein therapy; Cell and gene therapy; Polymeric drug delivery system; ENDOTHELIAL GROWTH-FACTOR; MESENCHYMAL STEM-CELLS; CONTROLLED-RELEASE; GENE-TRANSFER; THERAPEUTIC ANGIOGENESIS; MYOCARDIAL-INFARCTION; PROTEIN RELEASE; DOUBLE-BLIND; ISCHEMIA/REPERFUSION INJURY; ALGINATE HYDROGELS;

D O I：

10.1016/j.jconrel.2009.06.016

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Ischemic heart disease is a rapidly increasing common cause of death in the world. This disease is the insufficient status of oxygen within the cardiac muscles due to an imbalance between oxygen supply and demand, and a cardiac disease that occurs as a result of coronary artery stenosis. Conventional surgery-based therapy for the treatment of ischemic heart diseases has been advanced with biopharmaceutical-based therapy, such as protein, gene and cell therapy. The conventional medical therapy focuses on the use of drug eluting stents, coronary-artery bypass-graft surgery and anti-thrombosis. Biopharmaceutical-based therapies including recombinant protein therapy, gene therapy and cell transplantation are recognized as promising approaches in inducing neovascularization and improving collateral blood flow in the ischemic heart. This review explores the current status and future of the treatment of ischemic heart diseases with conventional medical therapy, biopharmaceutical-based therapy focused on the proteins and polymeric hydrogels for delivery of therapeutic proteins. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：194 / 202

页数：9

共 115 条

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