Imidapril inhibits increased transforming growth factor-beta 1 expression in remnant kidney model

被引：6

作者：

Hamaguchi, A

Kim, S

Wanibuchi, H

Iwao, H

机构：

[1] OSAKA CITY UNIV,SCH MED,DEPT PHARMACOL,OSAKA 545,JAPAN

[2] OSAKA CITY UNIV,SCH MED,DEPT PATHOL 1,OSAKA 545,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1997年 / 331卷 / 01期

关键词：

angiotensin-converting enzyme inhibitor; TGF-beta 1 (transforming growth factor-beta 1); extracellular matrix; glomerulosclerosis; gene expression;

D O I：

10.1016/S0014-2999(97)01036-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To elucidate the effect of imidapril, an angiotensin-converting enzyme inhibitor, on molecular events in progressive glomerulosclerosis, we administered imidapril to 5/6 nephrectomized rats and measured the glomerular expression of genes for transforming growth factor (TGF)-beta 1, fibronectin and collagen IV. Glomerular TGF-beta 1, fibronectin and collagen IV mRNAs in nephrectomized rats were significantly higher than those in sham-operated rats. Treatment with imidapril for 10 weeks significantly reduced the enhanced glomerular expression of TGF-beta 1 and collagen IV mRNA in nephrectomized rats, and prevented the associated proteinuria and glomerulosclerosis. Thus, imidapril may arrest progressive glomerulosclerosis by inhibiting the expression of TGF-beta 1 and collagen IV. (C) 1997 Elsevier Science B.V.

引用

页码：27 / 30

页数：4

共 16 条

[1] THERAPEUTIC ADVANTAGE OF CONVERTING ENZYME-INHIBITORS IN ARRESTING PROGRESSIVE RENAL-DISEASE ASSOCIATED WITH SYSTEMIC HYPERTENSION IN THE RAT [J].