Transcriptional control of T cell development

被引：22

作者：

Osborne, BA ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Vet & Anim Sci, Paige Lab 311, Amherst, MA 01003 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(00)00091-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transcriptional control of T cell development is a complex and rapidly moving area of investigation. Recent advances reveal critical roles for several transcription factors in T cell commitment, differentiation and selection. In particular, new roles for E proteins as well as members of the Notch signaling pathway have been described. Additionally a unique function of Ikaros in chromatin remodeling reveals a novel mechanism by which transcriptional control may be exerted.

引用

页码：301 / 306

页数：6

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