Community-acquired methicillin-resistant Staphylococcus aureus:: the role of Panton-Valentine Leukocidin

被引:386
作者
Boyle-Vavra, Susan [1 ]
Daum, Robert S. [1 ]
机构
[1] Univ Chicago, Dept Pediat, Infect Dis Sect, Chicago, IL 60637 USA
关键词
Panton-Valentine Leukocidin virulent; methicillin resistance; community-acquired; Staphylococcus aureus; necrotizing pneumonia; severe sepsis;
D O I
10.1038/labinvest.3700501
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Community-acquired (CA) methicillin-resistant Staphylococcus aureus (MRSA) infection among individuals without healthcare-associated (HA) risk factors was first recognized about a decade ago. It has now emerged as an epidemic that is responsible for rapidly progressive, fatal diseases including necrotizing pneumonia, severe sepsis and necrotizing fasciitis. Unlike HA-MRSA, CA-MRSA are usually pan-susceptible to non-beta-lactam antimicrobials. In addition to novel methicillin resistance genetic cassettes, many CA-MRSA harbor a phage harboring Panton-Valentine Leukocidin (PVL) genes and some data support the idea that PVL is responsible at least in part for the increased virulence of CA-MRSA. The tight association between the novel methicillin resistance cassettes and PVL phage cannot be explained, as they integrate into distinct sites on the S. aureus chromosome. This paper presents the evidence that CA-MRSA isolates are distinct strains emerging de novo from CA-methicillin susceptible isolates rather than from HA-MRSA isolates that have escaped from the hospital setting and that these novel CA-MRSA isolates may be more virulent than HA-MRSA. The second aim is to outline the progress in understanding the role of PVL in CA-MRSA pathogenesis.
引用
收藏
页码:3 / 9
页数:7
相关论文
共 32 条
[1]   Brief report:: Staphylococcus aureus sepsis and the waterhouse-friderichsen syndrome in children [J].
Adem, PV ;
Montgomery, CP ;
Husain, AN ;
Koogler, TK ;
Arangelovich, V ;
Humilier, M ;
Boyle-Vavra, S ;
Daum, RS .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (12) :1245-1251
[2]   Colonisation by Streptococcus pneumoniae and Staphylococcus aureus in healthy children [J].
Bogaert, D ;
van Belkum, A ;
Sluijter, M ;
Luijendijk, A ;
de Groot, R ;
Rümke, HC ;
Verbrugh, HA ;
Hermans, PWM .
LANCET, 2004, 363 (9424) :1871-1872
[3]   Successful multiresistant community-associated methicillin-resistant Staphylococcus aureus lineage from Taipei, Taiwan, that carries either the novel staphylococcal chromosome cassette mec (SCCmec) type VT or SCCmec type IV [J].
Boyle-Vavra, S ;
Ereshefsky, B ;
Wang, CC ;
Daum, RS .
JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (09) :4719-4730
[4]   Community-adapted methicillin-resistant Staphylococcus aureus (MRSA):: Population dynamics of an expanding community reservoir of MRSA [J].
Carleton, HA ;
Diep, BA ;
Charlebois, ED ;
Sensabaugh, GF ;
Perdreau-Remington, F .
JOURNAL OF INFECTIOUS DISEASES, 2004, 190 (10) :1730-1738
[5]   STAPHYLOCOCCUS-AUREUS LEUKOCIDIN - A NEW VIRULENCE FACTOR IN CUTANEOUS INFECTIONS - AN EPIDEMIOLOGIC AND EXPERIMENTAL-STUDY [J].
CRIBIER, B ;
PREVOST, G ;
COUPPIE, P ;
FINCKBARBANCON, V ;
GROSSHANS, E ;
PIEMONT, Y .
DERMATOLOGY, 1992, 185 (03) :175-180
[6]   A novel methicillin-resistance cassette in community- acquired Methicillin-resistant Staphylococcus aureus isolates of diverse genetic backgrounds [J].
Daum, RS ;
Ito, T ;
Hiramatsu, K ;
Hussain, F ;
Mongkolrattanothai, K ;
Jamklang, M ;
Boyle-Wang, S .
JOURNAL OF INFECTIOUS DISEASES, 2002, 186 (09) :1344-1347
[7]   Staphylococcus aureus isolates associated with necrotizing pneumonia bind to basement membrane type I and IV collagens and laminin [J].
de Bentzmann, S ;
Tristan, A ;
Etienne, J ;
Brousse, N ;
Vandenesch, F ;
Lina, G .
JOURNAL OF INFECTIOUS DISEASES, 2004, 190 (08) :1506-1515
[8]   Roles of 34 virulence genes in the evolution of hospital- and community-associated strains of methicillin-resistant Staphylococcus aureus [J].
Diep, BA ;
Carleton, HA ;
Chang, RF ;
Sensabaugh, GF ;
Perdreau-Remington, F .
JOURNAL OF INFECTIOUS DISEASES, 2006, 193 (11) :1495-1503
[9]   Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus [J].
Diep, BA ;
Gill, SR ;
Chang, RF ;
Phan, TH ;
Chen, JH ;
Davidson, MG ;
Lin, F ;
Lin, J ;
Carleton, HA ;
Mongodin, EF ;
Sensabaugh, GF ;
Perdreau-Remington, F .
LANCET, 2006, 367 (9512) :731-739
[10]   The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA) [J].
Enright, MC ;
Robinson, DA ;
Randle, G ;
Feil, EJ ;
Grundmann, H ;
Spratt, BG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (11) :7687-7692