In vitro display technologies -: new tools for drug discovery

被引：38

作者：

FitzGerald, K ^{[1
]}

机构：

[1] Actinova Ltd, Lib Technol, Cambridge CB4 0GA, England

来源：

DRUG DISCOVERY TODAY | 2000年 / 5卷 / 06期

关键词：

D O I：

10.1016/S1359-6446(00)01501-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Over the past decade, several ligand discovery techniques have been developed that mimic the process of natural evolution. Phage display technology is the most established of these methods and has been applied to numerous technological problems including the discovery of novel drugs. More recently, some new display technologies have emerged which, unlike phage display, operate entirely in vitro and have con-comitant advantages, This review describes this new generation of display technologies and indicates how they might fit into the modern drug discovery process.

引用

页码：253 / 258

页数：6

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