Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis

被引：30

作者：

Gaebele, Erwin ^{[1
]}

Muehlbauer, Marcus ^{[1
]}

Paulo, Hartwig ^{[1
]}

Johann, Monika ^{[2
]}

Meltzer, Christin ^{[1
]}

Leidl, Franz ^{[1
]}

Wodarz, Norbert ^{[2
]}

Wiest, Reiner ^{[1
]}

Schoelmerich, Juergen ^{[1
]}

Hellerbrand, Claus ^{[1
]}

机构：

[1] Univ Med Ctr Regensburg, Dept Internal Med 1, D-93042 Regensburg, Germany

[2] Univ Med Ctr Regensburg, Dept Psychiat, D-93042 Regensburg, Germany

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2009年 / 15卷 / 44期

关键词：

Monocyte chemotactic protein-1; Chemokines; Spontaneous bacterial peritonitis; Polymorphism; Liver cirrhosis; MONOCYTE CHEMOATTRACTANT PROTEIN-1; ENDOTHELIAL GROWTH-FACTOR; NITRIC-OXIDE PRODUCTION; CIRRHOTIC-PATIENTS; LIVER-DISEASE; MCP-1; GENE; PROMOTER POLYMORPHISM; ACUTE-INFLAMMATION; REGULATORY REGION; UP-REGULATION;

D O I：

10.3748/wjg.15.5558

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

AIM: To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1) gene in patients with spontaneous bacterial peritonitis (SBP). METHODS: MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites. RESULTS: The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However, in the subgroup of patients with alcoholic cirrhosis (n = 80), carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%, P = 0.021). CONCLUSION: In patients with alcoholic liver cirrhosis, the -2518 MCP-1 genotype AA is a risk factor for the development of SBP. (C) 2009 The WJG Press and Baishideng. All rights reserved

引用

页码：5558 / 5562

页数：5

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