Hyperthyroidism and mitochondrial uncoupling

被引：6

作者：

Luvisetto, S

机构：

[1] CNR Biomembranes Unit, Dept. of Exp. Biomedical Sciences, I-35121 Padova

来源：

BIOSCIENCE REPORTS | 1997年 / 17卷 / 01期

关键词：

hyperthyroidism; mitochondria; uncoupling; proton-leak; pump-slip;

D O I：

10.1023/A:1027379000027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During the past years many efforts have been made to elucidate the origin of the uncoupling mechanisms induced by hyperthyroidism in mitochondria. Two main mechanisms have been proposed: a classical protonophoric uncoupler mechanism, considering the action of thyroid hormones at the level of the lipid membrane bilayer, and a slipping mechanism with more localized effects at the lever of the redox proton pumps. This short review is devoted to comparing and discussing the evidence against and in favour of these two mechanisms.

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页码：17 / 21

页数：5

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