Optical imaging of bacterial infection in living mice using a fluorescent near-infrared molecular probe

被引：219

作者：

Leevy, W. Matthew

Gammon, Seth T.

Jiang, Hua

Johnson, James R.

Maxwell, Dustin J.

Jackson, Erin N.

Marquez, Manuel

Piwnica-Worms, David

Smith, Bradley D.

机构：

[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

[2] Philip Morris Inc, Interdisciplinary Network Emerging Sci & Technol, NEST, Grp Postgrad Program, Richmond, VA 23234 USA

[3] Philip Morris Inc, Res Ctr, Richmond, VA 23234 USA

[4] Washington Univ, Sch Med, Mallinckrodt Inst Radiol, Mol Imaging Ctr, St Louis, MO 63110 USA

[5] Chinese Acad Sci, Inst Chem, Key Lab Photochem, Beijing 100080, Peoples R China

[6] NIST, Ctr Theoret & Computat Nanosci, Gaithersburg, MD 20899 USA

[7] Arizona State Univ, Harrington Dept Bioengn, Tempe, AZ 85287 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 51期

关键词：

D O I：

10.1021/ja0665592

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An optical imaging probe was synthesized by attaching a near-infrared carbocyanine fluorophore to an affinity group containing two zinc(II) dipicolylamine (Zn-DPA) units. The probe has a strong and selective affinity for the surfaces of bacteria, and it was used to image infections of Gram-positive S. aureus and Gram-negative E. coli bacteria in living nude mice. After intravenous injection, the probe selectively accumulates at the sites of localized bacterial infections in the thigh muscles of the mice. Copyright © 2006 American Chemical Society.

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收藏

页码：16476 / 16477

页数：2

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