Effects of CGRP on human osteoclast-like cell formation: a possible connection with the bone loss in neurological disorders?

被引：50

作者：

Akopian, A ^{[1
]}

Demulder, A ^{[1
]}

Ouriaghli, F ^{[1
]}

Corazza, F ^{[1
]}

Fondu, P ^{[1
]}

Bergmann, P ^{[1
]}

机构：

[1] Free Univ Brussels, CHU Brugmann, Lab Expt Hematol, B-1020 Brussels, Belgium

来源：

PEPTIDES | 2000年 / 21卷 / 04期

关键词：

CGRP; osteoclast-like cell; disuse osteoporosis; neurological disorders;

D O I：

10.1016/S0196-9781(00)00185-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Osteoclast-like cell (OCL-like) differentiation is increased in long term cultures of bone marrow taken from paralyzed areas of paraplegic patients. Among the neuropeptides recently described in bone, calcitonin gene-related peptide (CGRP) has been shown in animal studies to inhibit bone resorption in vivo and OCL-like differentiation in vitro: its deficiency could thus be a link between the neural lesion and increased OCL-like production in paraplegia and some other neurologic disorders. We therefore investigated in this study the effects of CGRP on human OCL-like formation and found that it indeed has an inhibitory effect mediated at least in part via cAMP. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：559 / 564

页数：6

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