Association of selective HLA class II susceptibility-conferring and protective haplotypes with type 2 diabetes in patients from Bahrain and Lebanon

被引：11

作者：

Almawi, Wassim Y.

Wakim-Ghorayeb, Saria F.

Arekat, Mona R.

Najm, Pierre

Keleshian, Sose H.

Al-Sayed, Nasreen

Blanchon, Bruno

Sarnaha, Hanady R.

Irani-Hakime, Noha

机构：

[1] Arabian Gulf Univ, Coll Med & Med Sci, Dept Biochem Med, Manama, Bahrain

[2] Joslin Diabet Ctr, Manama, Bahrain

[3] St Georges Univ Hosp, Beirut, Lebanon

[4] Haigazian Univ, Beirut, Lebanon

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2006年 / 13卷 / 11期

关键词：

D O I：

10.1128/CVI.00206-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

The association of HLA class II with type 2 diabetes (T2DM) was investigated in Bahraini and Lebanese subjects. DRB1*070101 (Lebanese and Bahraini) and DQB1*0201 (Lebanese) were susceptibility-conferring alleles, and unique susceptibility-conferring/protective haplotypes were found in both patient groups. Regression analysis confirmed that DRB1*070101-DQB1*0201 (Bahraini) and DRB1*110101-DQB1*0201 (Lebanese) were susceptibility-conferring haplotypes.

引用

收藏

页码：1296 / 1298

页数：3

相关论文

共 20 条

[1]

Contribution of selective HLA-DRB1/DQB1 alleles and haplotypes to the genetic susceptibility of type 1 diabetes among Lebanese and Bahraini Arabs [J].

Al-Jenaidi, FA ;

Wakim-Ghorayeb, SF ;

Al-Abbasi, A ;

Arekat, MR ;

Irani-Hakime, N ;

Najm, P ;

Al-Ola, K ;

Motala, AA ;

Almawi, WY .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (09) :5104-5109

[2]

High prevalence of diabetes in Bahrainis - Associations with ethnicity and raised plasma cholesterol [J].

Al-Mahroos, F ;

McKeigue, PM .

DIABETES CARE, 1998, 21 (06) :936-942

[3]

HLA class II profile and distribution of HLA-DRB1 and HLA-DQB1 alleles and haplotypes among Lebanese and Bahraini Arabs [J].

Almawi, WY ;

Busson, M ;

Tamim, H ;

Al-Harbi, EM ;

Finan, RR ;

Wakim-Ghorayeb, SF ;

Motala, AA .

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2004, 11 (04) :770-774

[4]

High affinity presentation of an autoantigenic peptide in type I diabetes by an HLA class II protein encoded in a haplotype protecting from disease [J].

Bach, JM ;

Otto, H ;

Nepom, GT ;

Jung, G ;

Cohen, H ;

Timsit, J ;

Boitard, C ;

vanEndert, PM .

JOURNAL OF AUTOIMMUNITY, 1997, 10 (04) :375-386

[5]

Genetics of Type 2 diabetes [J].

Barroso, I .

DIABETIC MEDICINE, 2005, 22 (05) :517-535

[6]

IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes (UKPDS 71) [J].

Bottazzo, GF ;

Bosi, E ;

Cull, CA ;

Bonifacio, E ;

Locatelli, M ;

Zimmet, P ;

Mackay, IR ;

Holman, RR .

DIABETOLOGIA, 2005, 48 (04) :703-708

[7]

HLA in Czech adult patients with autoimmune diabetes mellitus: comparison with Czech children with type 1 diabetes and patients with type 2 diabetes [J].

Cerna, M ;

Novota, P ;

Kolostova, K ;

Cejkova, P ;

Zdarsky, E ;

Novakova, D ;

Kucera, P ;

Novak, J ;

Andel, M .

EUROPEAN JOURNAL OF IMMUNOGENETICS, 2003, 30 (06) :401-407

[8]

Increased frequency of HLA A2/DR4 and A2/DR8 haplotypes in young Saskatchewan aboriginal people with diabetic end-stage renal disease [J].

Dyck, R ;

Bohm, C ;

Klomp, H .

AMERICAN JOURNAL OF NEPHROLOGY, 2003, 23 (03) :178-185

[9]

Epidemiology of type 2 diabetes: Focus on ethnic minorities [J].

Egede, LE ;

Dagogo-Jack, S .

MEDICAL CLINICS OF NORTH AMERICA, 2005, 89 (05) :949-+

[10]

HLA-DRB1 alleles contribute to determining the prognosis of Japanese diabetes mellitus positive for antibodies to glutamate decarboxylase [J].

Fukui, M ;

Nakano, K ;

Nakamura, N ;

Maruya, E ;

Saji, H ;

Obayashi, H ;

Ohta, K ;

Ohta, M ;

Mori, H ;

Kajiyama, S ;

Wada, S ;

Kida, Y ;

Kosaka, K ;

Deguchi, M ;

Shigeta, H ;

Kitagawa, Y ;

Kondo, M .

JOURNAL OF CLINICAL IMMUNOLOGY, 1998, 18 (01) :89-92