Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod

被引：34

作者：

Abbo, Lillian

Vincek, Vladimir

Dickinson, Gordon

Shrestha, Niraj

Doblecki, Susanne

Haslett, Patrick A. J.

机构：

[1] Univ Miami, Miller Sch Med, Miami, FL 33152 USA

[2] Vet Adm Med Ctr, Miami, FL 33125 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2007年 / 44卷 / 03期

关键词：

D O I：

10.1086/510426

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report a case of acquired immunodeficiency syndrome ( AIDS) - associated, acyclovir- refractory genital herpes infection treated with topical imidazoquinoline therapy. The patient's plasmacytoid dendritic cells made a robust interferon-alpha response following in vitro stimulation with imidazoquinolinebut not with herpes simplex virus. We hypothesize that disease resulting from defective herpes simplex virus-stimulated interferona may be overcome by stimulating intact alternative pathways.

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页码：E25 / E27

页数：3

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