A Global Review on Short Peptides: Frontiers and Perspectives

被引：313

作者：

Apostolopoulos, Vasso ^{[1
]}

Bojarska, Joanna ^{[2
]}

Chai, Tsun-Thai ^{[3
]}

Elnagdy, Sherif ^{[4
]}

Kaczmarek, Krzysztof ^{[5
]}

Matsoukas, John ^{[1
,6
,7
]}

New, Roger ^{[8
,9
]}

Parang, Keykavous ^{[10
]}

Lopez, Octavio Paredes ^{[11
]}

Parhiz, Hamideh ^{[12
]}

Perera, Conrad O. ^{[13
]}

Pickholz, Monica ^{[14
,15
]}

Remko, Milan ^{[16
]}

Saviano, Michele ^{[17
]}

Skwarczynski, Mariusz ^{[18
]}

Tang, Yefeng ^{[19
]}

Wolf, Wojciech M. ^{[2
]}

Yoshiya, Taku ^{[20
]}

Zabrocki, Janusz ^{[5
]}

Zielenkiewicz, Piotr ^{[21
,22
]}

AlKhazindar, Maha ^{[4
]}

Barriga, Vanessa ^{[1
]}

Kelaidonis, Konstantinos ^{[6
]}

Sarasia, Elham Mousavinezhad ^{[9
]}

Toth, Istvan ^{[18
,23
,24
]}

机构：

[1] Victoria Univ, Inst Hlth & Sport, Melbourne, Vic 3030, Australia

[2] Lodz Univ Technol, Inst Gen & Ecol Chem, Fac Chem, Eromskiego 116, PL-90924 Lodz, Poland

[3] Univ Tunku Abdul Rahman, Dept Chem Sci, Fac Sci, Kampar 31900, Malaysia

[4] Cairo Univ, Dept Bot & Microbiol, Fac Sci, Gamaa St, Giza 12613, Egypt

[5] Lodz Univ Technol, Inst Organ Chem, Fac Chem, Zeromskiego 116, PL-90924 Lodz, Poland

[6] NewDrug, Patras Sci Pk, Patras 26500, Greece

[7] Univ Calgary, Cumming Sch Med, Dept Physiol & Pharmacol, Calgary, AB T2N 4N1, Canada

[8] Vaxcine UK Ltd, London Biosci Innovat Ctr, London NW1 0NH, England

[9] Middlesex Univ, Fac Sci & Technol, London NW4 4BT, England

[10] Chapman Univ, Sch Pharm, Dept Biomed & Pharmaceut Sci, Ctr Targeted Drug Delivery, Harry & Diane Rinker Hlth Sci Campus, Irvine, CA 92618 USA

[11] IPN, Ctr Invest & Estudios Avanzados, Dept Biotecnol & Bioquim, Irapuato 36824, Guanajuato, Mexico

[12] Univ Penn, Perelman Sch Med, Dept Med, Div Infect Dis, Philadelphia, PA 19104 USA

[13] Univ Auckland, Sch Chem Sci, Private Bag 92019, Auckland 1142, New Zealand

[14] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Fis, RA-1428 Buenos Aires, DF, Argentina

[15] UBA CONICET, Inst Fis Buenos Aires IFIBA, RA-1428 Buenos Aires, DF, Argentina

[16] Remedika, Luzna 9, Bratislava 85104, Slovakia

[17] CNR, Inst Crystallog, Via Amendola 122-o, I-70126 Bari, Italy

[18] Univ Queensland, Sch Chem & Mol Biosci, St Lucia, Qld 4072, Australia

[19] Tsinghua Univ, Sch Pharma Ceut Sci, Key Lab Bioorgan Phosphorus Chem & Chem Biol, MOE, Beijing 100084, Peoples R China

[20] Peptide Inst Inc, Osaka 5670085, Japan

[21] Polish Acad Sci, Inst Biochem & Biophys, Pawinskiego 5a, PL-02106 Warsaw, Poland

[22] Univ Warsaw, Inst Expt Plant Biol & Biotechnol, Dept Syst Biol, Miecznikowa 1, PL-02096 Warsaw, Poland

[23] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia

[24] Univ Queensland, Sch Pharm, Woolloongabba, Qld 4102, Australia

来源：

MOLECULES | 2021年 / 26卷 / 02期

基金：

中国国家自然科学基金;

关键词：

short peptides; constrained amino acids and peptide (bio)mimetics; drug design and drug; gene delivery; vaccines; aptamers; cell-penetrating peptides; synthesis; SARS-COV-2; cancer; bilayer interactions; altered peptide ligands; ant; super; agonists; diketopiperazine; cosmeceuticals; CELL-PENETRATING PEPTIDES; O-ACYL ISOPEPTIDE; MOLECULAR-DYNAMICS SIMULATION; CYCLOALIPHATIC C-ALPHA; C-ALPHA-DISUBSTITUTED GLYCINE; SEQUENCE-CONTAINING PEPTIDES; HISTIDINE-RELATED COMPOUNDS; EFFICIENT GENE DELIVERY; ARGININE-RICH PEPTIDES; POTENT ANGIOTENSIN-II; CYCLIC-PEPTIDES;

D O I：

10.3390/molecules26020430

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with protein-protein interactions, which are indispensable in bio-processes. Short peptides include fundamental molecular information for a prelude to the symphony of life. They have aroused considerable interest due to their unique features and great promise in innovative bio-therapies. This work focusing on the current state-of-the-art short peptide-based therapeutical developments is the first global review written by researchers from all continents, as a celebration of 100 years of peptide therapeutics since the commencement of insulin therapy in the 1920s. Peptide "drugs" initially played only the role of hormone analogs to balance disorders. Nowadays, they achieve numerous biomedical tasks, can cross membranes, or reach intracellular targets. The role of peptides in bio-processes can hardly be mimicked by other chemical substances. The article is divided into independent sections, which are related to either the progress in short peptide-based theranostics or the problems posing challenge to bio-medicine. In particular, the SWOT analysis of short peptides, their relevance in therapies of diverse diseases, improvements in (bio)synthesis platforms, advanced nano-supramolecular technologies, aptamers, altered peptide ligands and in silico methodologies to overcome peptide limitations, modern smart bio-functional materials, vaccines, and drug/gene-targeted delivery systems are discussed.

引用

页数：45

共 389 条

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ROLE OF HISTIDINE-RELATED COMPOUNDS TO INTRACELLULAR BUFFERING IN FISH SKELETAL-MUSCLE [J].