Review article: breath testing for human liver function assessment

被引:99
作者
Armuzzi, A
Candelli, M
Zocco, MA
Andreoli, A
De Lorenzo, A
Nista, EC
Miele, L
Cremonini, F
Cazzato, IA
Grieco, A
Gasbarrini, G
Gasbarrini, A
机构
[1] Univ Cattolica Sacro Cuore, Dept Internal Med, I-00168 Rome, Italy
[2] Univ Roma Tor Vergata, Rome, Italy
关键词
D O I
10.1046/j.1365-2036.2002.01374.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Carbon-labelled breath tests were proposed as tools for the evaluation of human liver function 30 years ago, but have never become part of clinical routine. One reason for this is the complex role of the liver in metabolic regulation, making it difficult to provide essential information for the management of patients with liver disease with a single test and to satisfy the hepatology community. As a result, a battery of breath tests have been developed. Depending on the test compound administered, different metabolic pathways (microsomal, cytosolic, mitochondrial) can be examined. Most available data come from microsomal function tests, whilst information about cytosolic and mitochondrial liver function is more limited. However, breath tests have shown promise in some studies, in particular to predict the outcome of patients with chronic liver disease or to monitor hepatic function after treatment. Whilst we await new substrates that can be used to measure liver function in a more valid manner, and large prospective studies to assess the usefulness of available test compounds, the aim of this review is to describe how far we have come in this controversial and unresolved issue.
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页码:1977 / 1996
页数:20
相关论文
共 188 条
[1]  
Adamek RJ, 1999, Z GASTROENTEROL, V37, P1139
[2]   FACTORS INFLUENCING SURVIVAL AT ONE YEAR IN PATIENTS WITH NONBILIARY HEPATIC PARENCHYMAL CIRRHOSIS [J].
ADLER, M ;
VANLAETHEM, J ;
GLIBERT, A ;
GELIN, M ;
BOURGEOIS, N ;
VEREERSTRAETEN, P ;
CREMER, M .
DIGESTIVE DISEASES AND SCIENCES, 1990, 35 (01) :1-5
[3]   LIVER-FUNCTION IN PROTEIN-ENERGY MALNUTRITION MEASURED BY CINNAMIC ACID TOLERANCE AND BENZOIC-ACID TOLERANCE - EFFECT OF CARNITINE SUPPLEMENTATION [J].
AHERN, DA ;
MITCHELL, ME .
BRITISH JOURNAL OF NUTRITION, 1989, 61 (02) :209-221
[4]   Pharmacokinetics and effect an caffeine metabolism of the proton pump inhibitors, omeprazole, lansoprazole, and pantoprazole [J].
Andersson, T ;
Holmberg, J ;
Röhss, K ;
Walan, A .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1998, 45 (04) :369-375
[5]  
[Anonymous], 1964, LIVER PORTAL HYPERTE
[6]  
[Anonymous], STABLE ISOTOPES
[7]   Non-invasive assessment of human hepatic mitochondrial function through the 13C-methionine breath test [J].
Armuzzi, A ;
Marcoccia, S ;
Zocco, MA ;
De Lorenzo, A ;
Grieco, A ;
Tondi, P ;
Pola, P ;
Gasbarrini, G ;
Gasbarrini, A .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2000, 35 (06) :650-653
[8]   STUDY OF THE DEMETHYLATION OF [1,3,7-ME-C-13] CAFFEINE IN MAN USING RESPIRATORY EXCHANGE MEASUREMENTS [J].
ARNAUD, MJ ;
THELINDOERNER, A ;
RAVUSSIN, E ;
ACHESON, KJ .
BIOMEDICAL MASS SPECTROMETRY, 1980, 7 (11-1) :521-524
[9]   CLINICAL UTILITY OF BREATH TESTS FOR THE ASSESSMENT OF HEPATIC-FUNCTION [J].
BAKER, AL ;
KOTAKE, AN ;
SCHOELLER, DA .
SEMINARS IN LIVER DISEASE, 1983, 3 (04) :318-329
[10]  
BARRY M, 1990, CLIN PHARMACOKINET, V47, P347